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Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March from the 10th to the 14th, 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Reason / purpose for cross-reference:
- reference to other study
- Remarks:
- validated analytical method
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- adopted July 27, 1995
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 13.24 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 24 - 72 h
- Temp.:
- 20 °C
- pH:
- 5.69 - 5.8
- Details on results:
- The water solubility of test item was determined to be 13.24 ± 3.96 g/l (95 % confidence interval) at 20 °C ± 0.5 °C using the flask method for the performance of the main test.
The repeatability of the determination was < 15 % and thus within the range required by the guidelines. - Conclusions:
- Water solubility: 13.24 ± 3.96 g/l at 20 °C and pH 5.69 - 5.80
- Executive summary:
Solubility was performed following the recommendations of the OECD method 105, by flask method.
A weight of ca. 4.1 g test item was weighed into 300 ml stoppered Erlenmeyer flasks (nine parallel). After the addition of 100 ml ultra pure water, the flasks were agitated at 30 °C. After one day, three of the vessels were removed and re-equilibrated at 20 ± 0.5 °C for 24 hours. The concentration in the clear solvent phase was determined by HPLC. The other flasks were treated similarly after initial equilibration at 30 °C for two and three days, respectively.
The water solubility of test item was determined to be 13.24 ± 3.96 g/l (95 % confidence interval) at 20 °C ± 0.5 °C using the flask method for the performance of the main test. The repeatability of the determination was < 15 %, thus within the range required by the guidelines
Conclusion
Water solubility: 13.24 ± 3.96 g/l at 20 °C and pH 5.69 - 5.80
Reference
Results of the determination of water solubility of test item
| Sampling time | Measured concentration of test item, g/l | Measured pH | |
| Test vessels | Mean | ||
| After 24h | 15.44 | 13.55 | 5.76 |
| 12.41 | 5.7 | ||
| 12.22 | 5.77 | ||
| After 48h | 15.18 | 14.77 | 5.72 |
| 14.19 | 5.75 | ||
| 14.96 | 5.69 | ||
| After 72h | 10.9 | 11.59 | 5.76 |
| 12.08 | 5.8 | ||
| 11.8 | 5.81 | ||
Mean with confidence interval (95 %) |
13.24 ± 3.96 | 5.75 | |
RSD % |
12 | ||
Description of key information
13.24 ± 3.96 g/l at 20 °C and pH 5.69 - 5.80
Key value for chemical safety assessment
- Water solubility:
- 13.24 g/L
- at the temperature of:
- 20 °C
Additional information
Flask method - OECD 105
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