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Diss Factsheets
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EC number: 240-385-4 | CAS number: 16294-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test material was not irritant on skin as well as mucous membranes of the rabbit eye
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study; Standard and non Standard test method, poor reporting and characterisation of test sample
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Remarks:
- Barail Test using injection
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 5 animals employed
- Principles of method if other than guideline:
- Skin was shaved at the flanks of rabbits. 0.2 ml of a solution of the test material in sesame oil were injected intracutaneously at concentrations of 10, 5, 1, 0.1, 0.01, and 0.001 %. The pure vehicle served as a control.
In a second part of the study 0.5 ml of the highest concentrations (5 & 10 %) were applied epidermally on the intact skin and evaluated visually. This treatment was repeated on 5 consecutive days. - GLP compliance:
- no
- Remarks:
- pre-dates GLP regulations
- Species:
- rabbit
- Strain:
- other: Yellow-Silver
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: no data
- Housing: individual cages
- Diet (e.g. ad libitum): Altromin ad lib.
- Water (e.g. ad libitum): no data
- Acclimation period: no dat
ENVIRONMENTAL CONDITIONS: no data - Type of coverage:
- other: Part 1: injection; Part 2: open
- Preparation of test site:
- shaved
- Vehicle:
- other: sesame oil
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.2 ml
- Concentration (if solution): 0 - 0.001- 0.01 -0.1- 1- 5-10 %
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.2 ml - Duration of treatment / exposure:
- no data
- Observation period:
- no data
- Number of animals:
- 5
- Irritation parameter:
- other: visual inspection and expert judgment
- Basis:
- mean
- Time point:
- other: no data
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: No scores were reported
- Irritant / corrosive response data:
- Injection of 5 and 10 % induced erythema of the skin. Epidermal treatment caused no effects.
- Other effects:
- no
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test material did no cause adverse reactions after epidermal application to the intact shaved skin of 5 rabbits.
- Executive summary:
Five daily epidermal applications of 5 and 10 % solutions of the test material in sesame oil to the shaved skin of rabbits caused no adverse reactions.
Intradermal injection of the test material into the shaved skin of rabbits at 0.001 to 10 % in sesame oil caused only mild reactions at 5% and higher.
The test material is considered non irritant after topical application.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study; no GLP; poor sample characterisation
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- reduced observation period (24h)
- GLP compliance:
- no
- Remarks:
- predates GLP
- Species:
- rabbit
- Strain:
- other: Yellow Silver
- Vehicle:
- other: sesame oil
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 24 h; no washing reported
- Observation period (in vivo):
- 24 h
- Number of animals or in vitro replicates:
- 5
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1-3-7-24 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: visual inspection, no scores reported; as there were no signs of irritation the score was set at 0
- Irritant / corrosive response data:
- no irritation
- Other effects:
- none
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material was not irritant to the eyes of rabbits
- Executive summary:
Eyes of five rabbits were exposed to 0.5 ml each of 5 and 10 % solutions of the test material. Effects were checked at 1, 3, 7 , and 24 hours after instillation.
No signs of irritation were detected at any time point.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The test material was not irritant on skin as well as mucous membranes of the rabbit eye. Although studies are quite old and not performed to todays standards, observations were reliably reported.
Justification for selection of skin irritation / corrosion endpoint:
Only available study
Justification for selection of eye irritation endpoint:
only available study
Justification for classification or non-classification
As no effects were observed in any study. No classification is warranted.
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