Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2006
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer); method similar to Annex V, A.8, 1.6.1, Directive 67/548/EEC
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006
Report Date:
2006

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
EU Method A.8 (Partition Coefficient)
Principles of method if other than guideline:
Based on the determined solubilities in water and in n-octanol the partition coefficient was estimated (chapter 1.6.1, A.8). Instead of saturated solvent
systems pure solvents were used.
Type of method:
other: calculation from individual solubilities
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
3.6
Temp.:
24 °C
pH:
ca. 7
Type:
Pow
Partition coefficient:
4 343
Temp.:
24 °C
pH:
ca. 7

Any other information on results incl. tables

Solubility of Solvent Orange 63 in n-octanol: 15.2 mg/l

Water solubility of Solvent Orange 63 : 3.5 µg/l

Pow SO63 = 4343

log Pow SO63 = 3.6

Applicant's summary and conclusion

Conclusions:
The Log Pow of the substance is 3.6 at 24°C (ambient temperature)
Executive summary:

The partition coefficient n-octanol/water was calculated from the individual solubilities of the substance in each of these solvents.

The analytical method for the determination is in agreement with the method that was agreed upon at the “Analytical Experts Meeting” of ETAD (Basel) on January 12, 2005.

The water solubility (chapter 4.8) was determined as 3.5 µg/L and the n-octanol solubility (chapter 4.9) as 15.2 mg/L (24°C, ambient temperature).

Out of these results the Log Pow can be calculated as 3.6