Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-941-9 | CAS number: 76-19-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- Data from reports from 1982 to 2011
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- Octafluoropropane is a gas, making testing technically difficult. However, as the attached reports explains, it can be considered a saturated perfluorocarbon, a class of compounds with near identical toxicology properties.
We have several toxicity reports supporting our position; the details in this end point are taken from the first, which is also the most recent.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
- Principles of method if other than guideline:
- SkinEthic exposed to subject material for 10 minutes. Viability of cells determined by their ability to reduce MTT. scored out of 100.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,1,1,2,2,3,3,4,5,5,5-undecafluoro-4-(trifluoromethyl)pentane
- EC Number:
- 206-575-6
- EC Name:
- 1,1,1,2,2,3,3,4,5,5,5-undecafluoro-4-(trifluoromethyl)pentane
- Cas Number:
- 355-04-4
- Molecular formula:
- C6F14
- IUPAC Name:
- 1,1,1,2,2,3,3,4,5,5,5-Undecafluoro-4-(trifluoromethyl)pentane
- Test material form:
- liquid: volatile
Constituent 1
Test animals / tissue source
- Species:
- other: SkinEthic
Test system
- Vehicle:
- unchanged (no vehicle)
Results and discussion
In vitro
Results
- Irritation parameter:
- other: Relativity viability
- Value:
- >= 93.2 - < 93.3
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on studies with other unsaturated perfluorocarbons, we can be confident octafluoropropane is not an eye irritant.
- Executive summary:
Based on studies with other unsaturated perfluorocarbons, together with experience of its use as a device in eye surgury, we can be confident octafluoropropane is not an eye irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
