Octafluoropropane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Justification for type of information:

As octafluoropropane is a gas, oral toxicity is not testable. However, acute oral toxicity has been performed on numerous perfluorocarbons, including 12 for which the study reports are attached. The data reported is for perfluorodecalin, as this is the most recent test report that we have.

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1996

Report date:

1996

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

1966

Report date:

1960

Reference 3

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Reference 4

Reference Type:

study report

Title:

Unnamed

Year:

1968

Report date:

1968

Reference 5

Reference Type:

study report

Title:

Unnamed

Year:

1989

Report date:

1989

Reference 6

Reference Type:

study report

Title:

Unnamed

Year:

1982

Report date:

1982

Reference 7

Reference Type:

study report

Title:

Unnamed

Year:

1989

Report date:

1989

Reference 8

Reference Type:

study report

Title:

Unnamed

Year:

1987

Report date:

1987

Reference 9

Reference Type:

study report

Title:

Unnamed

Year:

1969

Report date:

1969

Reference 10

Reference Type:

study report

Title:

Unnamed

Year:

1985

Report date:

1985

Reference 11

Reference Type:

study report

Title:

Unnamed

Year:

1983

Report date:

1983

Reference 12

Reference Type:

study report

Title:

Unnamed

Year:

1983

Report date:

1983

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test type:

fixed dose procedure

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Perflunafene

EC Number:

206-192-4

EC Name:

Perflunafene

Cas Number:

306-94-5

Molecular formula:

C10F18

IUPAC Name:

1,1,2,2,3,3,4,4,4a,5,5,6,6,7,7,8,8,8a-Octadecafluoronaphthalene

Test material form:

liquid

Test animals

Species:

rat

Strain:

Crj: CD(SD)

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

Single 2000 mg/kg dose

No. of animals per sex per dose:

5

Control animals:

not specified

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

other: Maximum dose tested to show non-toxic

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

None

Clinical signs:

other: None

Gross pathology:

No change

Other findings:

None

Applicant's summary and conclusion

Conclusions:

Octafluoropropane has no signidficant acute oral toxicity.

Executive summary:

Octafluoropropane has no signidficant acute oral toxicity.