Registration Dossier
Registration Dossier
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EC number: 200-941-9 | CAS number: 76-19-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Saturated perfluorocarbons are well established as a class of compounds with very similar toxicological properties.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Docosafluorododecahydrofluorene
- EC Number:
- 405-610-4
- EC Name:
- Docosafluorododecahydrofluorene
- Cas Number:
- 307-08-4
- Molecular formula:
- C13F22
- IUPAC Name:
- 1,1,2,2,3,3,4,4,4A,4B,5,5,6,6,7,7,8,8,8A,9,9,9A-Docosafluorododecahydro-1H-fluorene
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- S1178B
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Equal numbers of male and female HC/CFY 9remote Sprague-Dawley) rats, in a weight range 202 to 248 g, approximately 6 to 8 weeks old, all acclimated for a minimum of five days.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Hair removed from dorso-lumber by electric clippers. Test mateerial spread over prepared skin, then covered with gauze, held with an impermeable dressing.
- Duration of exposure:
- 24 hours
- Doses:
- Equivalent to 10% of the total body surface.
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- no indication of skin irritation up to the relevant limit dose level
- Mortality:
- None
- Clinical signs:
- other: None
- Gross pathology:
- None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute lethal dermal dose to rats of Flutec PP10 [perfluoroperhydrofluorene] was found to be greater than 2.0 g/kg bodyweight.
- Executive summary:
Material is essentially non-toxic.
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