Registration Dossier

Administrative data

First-aid measures

General advice
Move out of dangerous area. Place and transport victim in stable position (lying sideways). Remove contaminated clothing immediately and dispose of safely.

Inhalation
Move to fresh air. Keep patient warm and at rest. Call a physician or poison control center immediately.

Skin contact
Wash off thoroughly with plenty of soap and water, if available with polyethyleneglycol 400, subsequently rinse with water. If symptoms persist, call a physician.

Eye contact
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Get medical attention if irritation develops and persists.
Ingestion
Rinse mouth. Do NOT induce vomiting. Call a physician or poison control center immediately.
Most important symptoms and effects, both acute and delayed

Symptoms
No symptoms known or expected.
Indication of any immediate medical attention and special treatment needed

Treatment
Treat symptomatically. In case of ingestion gastric lavage should be considered in cases of significant ingestions only within the first 2 hours. However, the application of activated charcoal and sodium sulphate is always advisable. There is no specific antidote.

Fire-fighting measures

Extinguishing media
Suitable: Water spray, Carbon dioxide (CO2), Foam, Sand

Special hazards arising from the substance or mixture: In the event of fire the following may be released:, Hydrogen cyanide (hydrocyanic acid), Hydrogen fluoride, Carbon monoxide (CO), Nitrogen oxides (NOx), Sulphur oxides
Advice for firefighters

Special protective equipment for fire-fighters In the event of fire and/or explosion do not breathe fumes. In the event of fire, wear self-contained breathing apparatus.
Further information: Contain the spread of the fire-fighting media. Do not allow run-off from fire fighting to enter drains or water courses.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Precautions Avoid contact with spilled product or contaminated surfaces. Use personal protective equipment.

6.2 Environmental precautions
Do not allow to get into surface water, drains and ground water.
6.3 Methods and materials for containment and cleaning up

Methods for cleaning up Use mechanical handling equipment. Clean contaminated floors and objects thoroughly, observing environmental regulations. Keep in suitable, closed containers for disposal.

Handling and storage

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each manufacturing site.
Precautions for safe handling

Advice on safe handling Use only in area provided with appropriate exhaust ventilation.

Advice on protection against fire and explosion Keep away from heat and sources of ignition.
Hygiene measures Avoid contact with skin, eyes and clothing. Keep working clothes separately. Wash hands immediately after work, if necessary take a shower. Remove soiled clothing immediately and clean thoroughly before using again. Garments that cannot be cleaned must be destroyed (burnt).
7.2 Conditions for safe storage, including any incompatibilities

Requirements for storage areas and containers Store in original container. Keep containers tightly closed in a dry, cool and well-ventilated place. Store in a place accessible by authorized persons only. Keep away from direct sunlight.

Advice on common storage Keep away from food, drink and animal feedingstuffs.

7.3 Specific end uses
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.

Transport information

Land transport (ADR/RID)

UN number:
UN 3077
Proper shipping name and description:
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (SULFONYL-INDOL)
Chemical name:
1-[(difluoromethyl)sulfonyl]-3-(4,6-dimethoxy-1,3,5-triazin-
2-yl)-7-fluoro-1 H-indol-2-ol
Language:
English
Class:
9
Classification code:
M7
Packaging group:
III
Labels:
Packaging 9, E1
Bulk 9, E1
Haz ID 90
EAC 2Z
SpecialProvisionsopen allclose all

Inland waterway transport (ADN(R))

UN number:
UN 3077
Proper shipping name and description:
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (SULFONYL-INDOL)
Chemical name:
1-[(difluoromethyl)sulfonyl]-3-(4,6-dimethoxy-1,3,5-triazin-
2-yl)-7-fluoro-1 H-indol-2-ol
Language:
English
Class:
9
Classification code:
M7
Packaging group:
III
Labels:
Packaging 9, E1
Bulk 9, E1
Haz ID 90
Remarksopen allclose all

Marine transport (IMDG)

UN number:
UN 3077
Proper shipping name and description:
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (SULFONYL-INDOL)
Chemical name:
1-[(difluoromethyl)sulfonyl]-3-(4,6-dimethoxy-1,3,5-triazin-
2-yl)-7-fluoro-1 H-indol-2-ol
Class:
9
Packaging group:
III
EmS code:
F-A, S-F
Labels:
Packaging 9,P
Bulk 9,P
Marine pollutant
Remarksopen allclose all

Air transport ICAO/IATA

UN number:
UN 3077
Proper shipping name and description:
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (SULFONYL-INDOL)
Chemical name:
1-[(difluoromethyl)sulfonyl]-3-(4,6-dimethoxy-1,3,5-triazin-
2-yl)-7-fluoro-1 H-indol-2-ol
Class:
9
Packaging group:
III
Labels:
Packaging 9, E1
Remarksopen allclose all
SpecialProvisionsopen allclose all

Exposure controls / personal protection

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each manufacturing site.
Control parameters: No control parameters known.
Exposure controls


Respiratory protection If product is handled while not enclosed, and if contact may occur:
Wear respirator with a particle filter mask (protection factor 4) conforming to European norm EN149FFP1 or equivalent.
Respiratory protection should only be used to control residual risk of short duration activities, when all reasonably practicable steps have been taken to reduce exposure at source e.g. containment and/or local extract ventilation. Always follow respirator manufacturer's instructions regarding wearing and maintenance.
Hand protection Wear CE Marked (or equivalent) nitrile rubber gloves (minimum thickness of 0,4 mm). Wash when contaminated and dispose of when contaminated inside, when perforated or when contamination on the outside cannot be removed. Wash hands frequently and always before eating, drinking, smoking or using the toilet.

Eye protection Wear goggles (conforming to EN166, Field of Use = 5 or equivalent).

Skin and body protection Wear standard coveralls and Category 3 Type 4 suit.
If there is a risk of significant exposure, consider a higher protective type suit.
Wear two layers of clothing wherever possible. Polyester/cotton or cotton overalls should be worn under chemical protection suit and should be professionally laundered frequently.
If chemical protection suit is splashed, sprayed or significantly contaminated, decontaminate as far as possible, then carefully remove and dispose of as advised by manufacturer.

General protective measures If product is handled while not enclosed, and if contact may occur:
Complete suit protecting against chemicals

Stability and reactivity

Reactivity

Thermal decomposition
from 146 °C, Heating rate: 3 K/min


10.2 Chemical stability
Stable under recommended storage conditions.


10.3 Possibility of hazardous reactions
No hazardous reactions when stored and handled according to prescribed instructions.


10.4 Conditions to avoid
Extremes of temperature and direct sunlight.


10.5 Incompatible materials Store only in the original container.


10.6 Hazardous decomposition products No decomposition products expected under normal conditions of use.

Disposal considerations

During the whole life cycle of the substance all necessary measures in accordance to art. 18(4) of (EC) 1907/2006 are undertaken. The substance is handled under strictly controlled conditions.