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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Details not available
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Data has been provided by ECHA from a previous notification. The data has been reviewed by a suitable Competent Authority and adjudged to be suitable for registration.

Data source

Reference
Reference Type:
other: Provided by ECHA
Title:
Unnamed
Year:
2004

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
not specified
Qualifier:
according to guideline
Guideline:
EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzyltributylammonium 4-hydroxynaphthalene-1-sulfonate
EC Number:
402-240-5
EC Name:
Benzyltributylammonium 4-hydroxynaphthalene-1-sulfonate
Cas Number:
102561-46-6
Molecular formula:
C29H41NO4S
IUPAC Name:
benzyltributylammonium 4-hydroxynaphthalene-1-sulfonate
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
Details not available

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
Details not available

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
65 mg
Duration of treatment / exposure:
Not specified
Observation period (in vivo):
Not specified
Number of animals or in vitro replicates:
3
Details on study design:
Details not available

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Remarks:
(redness)
Basis:
mean
Time point:
other: overall at 24h, 48h & 72h
Score:
0.3
Max. score:
2
Reversibility:
fully reversible within: 48h
Remarks on result:
other: Max. duration: 48h; Max. value at end of observation period: 0 (related to all animals)
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: overall at 24h, 48h & 72h
Score:
0.3
Max. score:
2
Reversibility:
fully reversible within: 48h
Remarks on result:
other: Max. duration: 48h; Max. value at end of observation period: 0 (related to all animals)
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: overall at 24h, 48h & 72h
Score:
0
Remarks on result:
other: Max. duration: h; Max. value at end of observation period: 0 (related to all animals)
Irritation parameter:
iris score
Basis:
mean
Time point:
other: overall at 24h, 48h & 72h
Score:
0
Remarks on result:
other: Max. duration: h; Max. value at end of observation period: 0 (related to all animals)
Irritant / corrosive response data:
Reversilibity of any observed effect: Changes fully reversible within 2 days.
Other effects:
All three animals gave a "positive" response. Transient, mild conjunctival irritation only was observed.The eyes wer normal 2 days after instillation.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated informationCriteria used for interpretation of results: not specified
Conclusions:
Not irritating.
Executive summary:

The eye irritation was determined using the OECD 405 and EU B5 test methods. Details are not available, but the data has been reviewed by a suitable EU Competent Authority and provided by ECHA. The test substance is not irritating.