Registration Dossier
Registration Dossier
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EC number: 402-240-5 | CAS number: 102561-46-6 BONTRON P-51
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Details not available
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Data has been provided by ECHA from a previous notification. The data has been reviewed by a suitable Competent Authority and adjudged to be suitable for registration.
Data source
Reference
- Reference Type:
- other: Provided by ECHA
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Benzyltributylammonium 4-hydroxynaphthalene-1-sulfonate
- EC Number:
- 402-240-5
- EC Name:
- Benzyltributylammonium 4-hydroxynaphthalene-1-sulfonate
- Cas Number:
- 102561-46-6
- Molecular formula:
- C29H41NO4S
- IUPAC Name:
- benzyltributylammonium 4-hydroxynaphthalene-1-sulfonate
- Test material form:
- not specified
- Details on test material:
- Not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl : COBS CD (SD) BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Details not available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: 1% Aqueous methylcellulose
- Details on oral exposure:
- Details not available
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 males & 5 females
- Control animals:
- not specified
- Details on study design:
- Details not available
- Statistics:
- Not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- Male: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0Female: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0
- Clinical signs:
- Signs of toxicity related to dose levels:There were no deaths. Signs of reaction to treatment observed in all rats within three hours of dosing were piloerection, increased salivation, abnormal body carriage (hunched posture), abnormal gait (waddling) and diarrhoea. Complete recovery was reached 2 days after treatment.
- Body weight:
- Slightly low bodyweight gains were recorded on Day 8 for two male rats.
- Gross pathology:
- Terminal autopsy findings were normal. Effects on organs: None seen.
- Other findings:
- Not specified
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- LD50 >5000 mg/kg bw
- Executive summary:
The acute toxicity: oral was measured using the OECD 401 and EU B1 test methods. Details are not available, but the data has been reviewed by a suitable EU Competent Authority and provided by ECHA. LD50 >5000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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