Registration Dossier

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Details not available
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Data has been provided by ECHA from a previous notification. The data has been reviewed by a suitable Competent Authority and adjudged to be suitable for registration.

Data source

Reference
Reference Type:
other: Provided by ECHA
Title:
Unnamed
Year:
2004

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
not specified
Qualifier:
according to guideline
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzyltributylammonium 4-hydroxynaphthalene-1-sulfonate
EC Number:
402-240-5
EC Name:
Benzyltributylammonium 4-hydroxynaphthalene-1-sulfonate
Cas Number:
102561-46-6
Molecular formula:
C29H41NO4S
IUPAC Name:
benzyltributylazanium 4-hydroxynaphthalene-1-sulfonate
Test material form:
not specified
Details on test material:
Details not available

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
Details not available

Test system

Type of coverage:
semiocclusive
Preparation of test site:
not specified
Vehicle:
other: Distilled water
Controls:
not specified
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
4 hours
Observation period:
Not specified
Number of animals:
3
Details on study design:
Details not available

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: overall at 24, 48 & 72h
Score:
0
Irritation parameter:
edema score
Basis:
mean
Time point:
other: overall at 24, 48 & 72h
Score:
0
Irritant / corrosive response data:
Not specified
Other effects:
Not specified

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated informationCriteria used for interpretation of results: not specified
Conclusions:
Not irritating
Executive summary:

The skin irritation/corrosion was measured using the OECD 404 and EU B4 test methods. Details are not available, but the data has been reviewed by a suitable EU Competent Authority and provided by ECHA. The test substance is not irritating.