Registration Dossier
Registration Dossier
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EC number: 402-240-5 | CAS number: 102561-46-6 BONTRON P-51
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Details not available
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Data has been provided by ECHA from a previous notification. The data has been reviewed by a suitable Competent Authority and adjudged to be suitable for registration.
Data source
Reference
- Reference Type:
- other: Provided by ECHA
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Benzyltributylammonium 4-hydroxynaphthalene-1-sulfonate
- EC Number:
- 402-240-5
- EC Name:
- Benzyltributylammonium 4-hydroxynaphthalene-1-sulfonate
- Cas Number:
- 102561-46-6
- Molecular formula:
- C29H41NO4S
- IUPAC Name:
- benzyltributylammonium 4-hydroxynaphthalene-1-sulfonate
- Test material form:
- not specified
- Details on test material:
- Details not available
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Details not available
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- other: Distilled water
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Not specified
- Number of animals:
- 3
- Details on study design:
- Details not available
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: overall at 24, 48 & 72h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: overall at 24, 48 & 72h
- Score:
- 0
- Irritant / corrosive response data:
- Not specified
- Other effects:
- Not specified
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated informationCriteria used for interpretation of results: not specified
- Conclusions:
- Not irritating
- Executive summary:
The skin irritation/corrosion was measured using the OECD 404 and EU B4 test methods. Details are not available, but the data has been reviewed by a suitable EU Competent Authority and provided by ECHA. The test substance is not irritating.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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