Registration Dossier
Registration Dossier
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Reaction mass of tetrasodium [mono(4,4'-(1Z,1'Z)-(4,4'-dioxidobiphenyl-3,3'-diyl)bis(diazene-2,1-diyl)bis(5-amino-3-oxidonaphthalene-2,7-disulfonate(3-)) cuprate (4-)] and tetraammonium [mono(4,4'-(1Z,1'Z)-(4,4'-dioxidobiphenyl-3,3'-diyl)bis(diazene-2,1-diyl)bis(5-amino-3-oxidonaphthalene-2,7-disulfonate(3-)) cuprate (4-)]
EC number: 943-486-8 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study has been presented to ECHA in the framework of a NONS notification. The document is now public because presented more than 12 years ago. The summary received is from migrated NONS dossier
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- Direct Blue 267
- IUPAC Name:
- Direct Blue 267
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Duration of exposure:
- 24h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw, number of deaths: 0Female: 2000 mg/kg bw, number of deaths: 0
- Clinical signs:
- other: Signs of toxicity related to dose levels: no deaths and no treatment related sign of toxicity
- Gross pathology:
- Effects on organs: no treatment related sign of toxicity
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information under Regulation 1272/2008 Criteria used for interpretation of results: EU
- Conclusions:
- The analogue substance was tested for acute dermal toxicity following EU Method B3. Under the experimental conditions the LD50 > 2000 mg/kg bw.
- Executive summary:
The analogue substance was tested for acute dermal toxicity following EU Method B3. Under the experimental conditions the LD50 > 2000 mg/kg bw
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