Registration Dossier
Registration Dossier
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EC number: 213-427-4 | CAS number: 947-42-2
Endpoint summary
Administrative data
Description of key information
The key study for skin irritation (Hazelton, 1987c), found diphenylsilanediol to be non-irritant to skin. In the key study for eye irritation (Hazelton, 1987d) diphenylsilanediol was found to be slightly irritating to eyes but did not meet current EU criteria for classification for this endpoint.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the key study for skin irritation (Hazelton, 1987c), diphenylsilanediol was found to be non-irritating in a study conducted according to OECD Test Guideline 404 and in compliance with GLP.
In the key study for eye irritation (Hazelton, 1987d), conducted according to OECD Test Guideline 405 and in compliance with GLP, diphenylsilanediol was found to be slightly irritating with the neat material causing slight conjunctival erythema and iritis. The conjunctival effects were reversible within 48 hours in all animals. The iris effects were reversible within 48 hours for one animal and within 72 hours for a further three animals. Iris effects were still noted in two animals at 72 hours but there were no further observations made.
Justification for selection of skin irritation / corrosion endpoint:
Study was conducted according to an appropriate guideline and in compliance with GLP.
Justification for selection of eye irritation endpoint:
Study was conducted according to an appropriate guideline and in compliance with GLP.
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
Based on the available data diphenylsilanediol does not require classification for skin or eye irritation according to Regulation (EC) No 1272/2008.
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