Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 943-428-1 | CAS number: -
According to Article 13 of Regulation (EC) No 1907/2006 "General Requirements for Generation of Information on Intrinsic Properties of Substances", Information on intrinsic properties of substances may be generated by means other than tests e.g. from information from structurally related substances (grouping or read-across), provided that conditions set out in Annex XI are met. Annex XI, "General rules for adaptation of this standard testing regime set out in Annexes VII to X” states that “substances whose physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity may be considered as a group, or ‘category’ of substances. This avoids the need to test every substance for every endpoint”. Since the read-across concept is applied for selected endpoint, data will be generated from a representative source substance to avoid unnecessary animal testing. Additionally, once the read-across concept is applied, substances will be classified and labelled on this basis.
Brief description of the data relevant for classification
Biodegradation: readily biodegradable: 62.5% to 88% after 28 d (OECD 301 C and F); read-across
Low potential for bioaccumulation.
Aquatic acute toxicity
· RA CAS 1338-41-6: LL50 (96 h, Oryzias latipes) > 1000 mg/L (nominal, WAF)
· RA CAS 1338-39-2: LC50 (96 h, Danio rerio) > 100 mg/L (nominal)
· RA CAS 9005-64-5: LL50 (96 h, Danio rerio) > 100 mg/L (nominal)
· RA CAS 1338-41-6: EL50 (48 h, Daphnia magna) >1000 mg test item/L (nominal)
· RA CAS 1338-39-2: LL50 (48 h, Acartia tonsa) = 452.84 mg test item/L (nominal, WAF)
· RA CAS 1338-41-6: EL50 (72 h, Pseudokirchneriella subcapitata) >1000 mg/L (nominal, WAF, based on growth rate)
· RA CAS 1338-39-2: EL50 (72 h, Skeletonema costatum) = 17.89 mg/L (nominal, WAF, based on growth rate)
· RA CAS 9005-64-5: EL50 (72 h, Pseudokirchnerella subcapitata) = 58.84 mg/L (nominal, WAF, based on growth rate)
Aquatic chronic toxicity
Fish: no data available
· RA CAS 1338-41-6: NOELR (21 d, Daphnia magna) ≥ 16 mg/L (nominal, based on cumulative number of juveniles produced per adult
· RA CAS 9005-64-5: NOELR (21, Daphnia magna) = 10 mg/L (nominal, WAF)
· RA CAS 1338-41-6: NOELR (72 h, Pseudokirchneriella subcapitata) = 560 mg/L (nominal, WAF, based on growth rate)
· RA CAS 1338-39-2: NOELR (72 h, Skeletonema costatum) ≥ 10 mg/L (nominal, WAF, based on growth rate)
· RA CAS 9005-64-5: EL10 (72 h, Pseudokirchnerella subcapitata) = 19.05 mg/L (nominal, WAF, based on growth rate)
Conclusion on classification
Based on the data above, sorbitan C16-18 (even numbered) fatty acid esters, ethoxylated (1-6.5 moles ethoxylated) is considered to be rapidly biodegradable. The acute aquatic toxicity L(E) C(L)50 values are ≥17.89 mg/L. Chronic toxicity data are additionally available for aquatic invertebrates and algae. The lowest NOELR value is 10 mg/L. Therefore, sorbitan C16-18 (even numbered) fatty acid esters, ethoxylated (1-6.5 moles ethoxylated) does not need to be classified and labelled for acute or long-term hazards to the aquatic environment according to the 6th ATP of the Regulation (EC) No 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again