Registration Dossier
Registration Dossier
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EC number: 460-450-2 | CAS number: 872728-82-0
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 2000/32/EG, B.13, B.14 (Ames-Test)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: sat TA 98, 100, 1535, 1537, esc WP2 uvrA
- Metabolic activation system:
- Rat-liver post mitochondrial supernatant (S9 fraction). Rat liver enzymes were induced with phenobarbital and beta- naphthoflavone.
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 31.62 ... 5000 µg/plate
Concentration range in the main test (without metabolic activation): 31.62 ... 5000 µg/plate - Vehicle / solvent:
- Solvent: DMSO (dimethylsulfoxide)
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 µg/plate)
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 µg/plate)
- Remarks on result:
- other: other: preliminary test
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
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