Glycine, N-[4-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)phenyl]-

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Adequacy of study:

other information

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: 92/69/EWG, B.3

GLP compliance:

yes

Limit test:

yes

Test animals

Species:

other: rat, Wistar Crl:(WI) BR

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

other: No vehicle used. The test article was moistened with distilled water.

Duration of exposure:

24 h

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0

Clinical signs:

other: Signs of toxicity related to dose levels: No treatment related mortality, clinical signs were noted. Most animals showed a reduced weight gain in the first week after treatment.

Gross pathology:

Effects on organs:
No treatment related macroscopic findings were noted.

Other findings:

Signs of toxicity (local):
No treatment related skin reactions were noted.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU