Registration Dossier
Registration Dossier
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EC number: 910-245-3 | CAS number: -
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- other: Assessment
- Type of information:
- other: Expert Assessment
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Expert assessment as opposed to experimental result
Data source
Reference
- Reference Type:
- other: Expert assessment
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
- Principles of method if other than guideline:
- Assessment
- GLP compliance:
- no
Test material
- Reference substance name:
- Reaction mass of disodium metasilicate and sodium hydroxide
- EC Number:
- 910-245-3
- Molecular formula:
- NaOH Na2SiO3
- IUPAC Name:
- Reaction mass of disodium metasilicate and sodium hydroxide
Constituent 1
Results and discussion
Effect levels
- Remarks on result:
- not measured/tested
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Assessment
Applicant's summary and conclusion
- Executive summary:
This substance is a multi-constituent substance consisting of sodium hydroxide (215-185-5, 1310-73-2) and disodium metasilicate (229-912-9, 6834-92-0). It is the by-product of a reaction between zircon (EC no 239-019-6) and sodium hydroxide; after hydrolysis, this substance is the water-soluble fraction. The substance in water has a pH of >13. The high pH makes repeated dose toxicity (oral) inappropriate for animal welfare reasons. Testing of this substance for chronic effects is unnecessary for the following reasons.
1. The reaction mass of disodium metasilicate and sodium hydroxide has a pH of >13 which, if tested for oral toxicity, would give localised effects dues to its corrosiveness.
2. Testing this substance would not add anything to the knowledge about its hazard profile than can be derived from the data for silicic acid, sodium salt and therefore this data is used as surrogate for the reaction mass of disodium metasilicate and sodium hydroxide.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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