Registration Dossier
Registration Dossier
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EC number: 910-245-3 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- other: Expert assessment
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Expert assessment as opposed to experimental result
Data source
Reference
- Reference Type:
- other: Expert Assessment
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
- Principles of method if other than guideline:
- Assessment
- GLP compliance:
- no
- Test type:
- other: Assessment
Test material
- Reference substance name:
- Reaction mass of disodium metasilicate and sodium hydroxide
- EC Number:
- 910-245-3
- Molecular formula:
- NaOH Na2SiO3
- IUPAC Name:
- Reaction mass of disodium metasilicate and sodium hydroxide
Constituent 1
Results and discussion
Effect levels
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
Assessment
Applicant's summary and conclusion
- Interpretation of results:
- other: Assessment
- Executive summary:
This substance is a multi-constituent substance consisting of sodium hydroxide (215-185-5, 1310-73-2) and disodium metasilicate (229-912-9, 6834-92-0). It is the by-product of a reaction between zircon (EC no 239-019-6) and sodium hydroxide; after hydrolysis, this substance is the water-soluble fraction. The substance has a pH of >13. Consequently, it could not be tested as is; the dermal toxicity study has been conducted for disodium metasilicate, which showed an LD50 of >5000 mg/kg. Running an acute dermal study on the reaction mass of disodium metasilicate and sodium hydroxide would add nothing to the hazard assessment for this substance, and risk management measures are driven primarily by its corrosive nature due to the high pH. Determination of acute toxicity by the dermal route is therefore considered unnecessary.
The above should be considered as an expert statement to waive the requirement for testing for acute toxicity by the dermal route under REACH Annex VIII for endpoint 8.5.3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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