Registration Dossier
Registration Dossier
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EC number: 910-245-3 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Sodium Hydroxide: Source - the sodium hydroxide summary risk assessment report JRC EC 2008
Although two inhalation studies showed local effects on the respiratory tract after repeated NaOH exposure, the data were not adequate to establish a N(L)OAEL because the exposure concentrations were not specified. Furthermore, no data with regard to repeated dermal toxicity was available. A limited oral drinking water study with rats revealed effects on growth. This effect can be explained by NaOH neutralising the acid environment in the stomach which decreases the digestion and the absorption of food.
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
Repeated dose studies would add nothing to the hazard assessment for this substance, and risk management measures are driven primarily by its corrosive nature due to the high pH. Determination of chronic toxicity is therefore considered inappropriate and unnecessary.
Justification for selection of repeated dose toxicity inhalation - systemic effects endpoint:
Repeated dose studies would add nothing to the hazard assessment for this substance, and risk management measures are driven primarily by its corrosive nature due to the high pH. Determination of chronic toxicity is therefore considered inappropriate and unnecessary.
Justification for selection of repeated dose toxicity inhalation - local effects endpoint:
Repeated dose studies would add nothing to the hazard assessment for this substance, and risk management measures are driven primarily by its corrosive nature due to the high pH. Determination of chronic toxicity is therefore considered inappropriate and unnecessary.
Justification for selection of repeated dose toxicity dermal - systemic effects endpoint:
Repeated dose studies would add nothing to the hazard assessment for this substance, and risk management measures are driven primarily by its corrosive nature due to the high pH. Determination of chronic toxicity is therefore considered inappropriate and unnecessary.
Justification for selection of repeated dose toxicity dermal - local effects endpoint:
Repeated dose studies would add nothing to the hazard assessment for this substance, and risk management measures are driven primarily by its corrosive nature due to the high pH. Determination of chronic toxicity is therefore considered inappropriate and unnecessary.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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