Registration Dossier

Physical & Chemical properties

Explosiveness

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Administrative data

Endpoint:
explosiveness
Type of information:
other: Theoretical assessment of the structure of the test substance
Adequacy of study:
supporting study
Study period:
Not applicable
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Although the testing facility indicated EU Method A14 was used, an experimental study using EU Method A14 was not conducted. Instead, a theoretical assessment of explosive properties of the test substance was conducted.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report Date:
2007

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.14 (Explosive properties)
Deviations:
no
Remarks:
The testing facility indicated that the protocol was followed without deviation.
Principles of method if other than guideline:
Not applicable
GLP compliance:
no
Remarks:
Not applicable as theoretical assessment

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): VRT-753136 hcl
- Molecular formula (if other than submission substance): not applicable
- Molecular weight (if other than submission substance): not applicable
- Smiles notation (if other than submission substance): not applicable
- InChl (if other than submission substance): not applicable
- Structural formula attached as image file (if other than submission substance): not applicable
- Substance type: no data
- Physical state: white powder
- Analytical purity: 99.4% w/w by High Performance Liquid Chromatography (HPLC)
- Impurities (identity and concentrations): individual unknown components were detected at 0.03 area%; isopropanol (residual solvent) at 300 ppm
- Composition of test material, percentage of components: not applicable
- Isomers composition: not applicable
- Purity test date: 2006-05-25
- Lot/batch No.: 25515
- Expiration date of the lot/batch: May 2008
- Stability under test conditions: no data
- Storage condition of test material: at room temperature
- Other: no data

Results and discussion

Small-scale preliminary testsopen allclose all
Parameter:
other: More sensitive to shock than m-dinitrobenzene
Remarks:
migrated information
Remarks on result:
not measured/tested
Parameter:
other: More sensitive to friction than m-dinitrobenzene
Remarks:
migrated information
Remarks on result:
not measured/tested
Parameter:
other: Explosive under influence of flame
Remarks:
migrated information
Remarks on result:
not measured/tested
Parameter:
other: Explosive (not specified)
Remarks:
migrated information
Remarks on result:
negative (not further specified)
Remarks:
: See "Remarks on results including tables and figures"

Any other information on results incl. tables

According to the United Nations Committee of Experts on the Transport of Dangerous Goods, explosive properties are associated with the presence of certain chemical groups in a molecule which can react to produce a very rapid increase in temperature or pressure. Thus, it is possible to examine the chemical structure of a substance and ascertain whether or not there are any groups present that are associated with explosive properties. For this purpose a list of screening procedures has been published in Appendix 6 of the United Nations ‘Recommendations on the Transport of Dangerous Goods, Manual of Tests and Criteria’. The initial assessment of explosive properties is made by examining the chemical structures of the components with a list of functional groups that may indicate explosive properties in organic materials, including: C-C- unsaturated bonds, C- or N-Metal bonds, contiguous nitrogen atoms, contiguous oxygen atoms, N-O bonds and N- or O-halogen bonds.

From an examination of the chemical structure of the test substance it was concluded that it contained no functional groups which are characteristic of explosive properties.

Applicant's summary and conclusion

Conclusions:
It was considered that the test substance was not explosive and therefore an assessment of this property was made using a theoretical assessment of the structure of the test substance.
Executive summary:

Not applicable