Registration Dossier
Registration Dossier
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EC number: 268-358-2 | CAS number: 68081-84-5 This substance is identified by SDA Substance Name: C10-C16 alkyl glycidyl ether and SDA Reporting Number: 15-076-00.
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Cited from ECHA disseminated dossier Query date: 2015-07-22 For justification of read across please refer to IUCLID section 13.
Data source
Reference
- Reference Type:
- other: ECHA disseminated dossier
- Title:
- No information
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- E. coli WP2 uvrA, or E. coli WP2 uvrA (pKM101), or S. typhimurium TA102 was not tested.
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 939-183-5
- EC Number:
- 939-183-5
- IUPAC Name:
- 939-183-5
- Details on test material:
- The test material was received from the principal on July 11, 1979.
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- S. typhimurium TA 1538
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 form male Wistar rats
- Test concentrations with justification for top dose:
- First experimental: 0, 0.005, 0.024, 0.12, 0.6 and 3 μl/ plate
Second experimental: 0, 0.024, 0.12, 3, 10 μl/ plate
Controls
- Untreated negative controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
The results obtained with test material and TA 1535, although indicative for slight mutagenic activity, are considered to be inconclusive, since toxicity of the test chemical for the bacteria interfered with the mutagenicity testing.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
