Registration Dossier
Registration Dossier
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EC number: 268-358-2 | CAS number: 68081-84-5 This substance is identified by SDA Substance Name: C10-C16 alkyl glycidyl ether and SDA Reporting Number: 15-076-00.
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- Between 12 February and 21 April 2012.
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Cited from ECHA disseminated dossier Query date: 2015-07-22 For justification of read across please refer to IUCLID section 13.
Data source
Reference
- Reference Type:
- other: ECHA disseminated dossier
- Title:
- No information
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Principles of method if other than guideline:
- The test system consisted of a high performance liquid chromatograph with a suitable detector (UV/VIS). A reverse phase HPLC column with a very low percentage of polar groups was used (e.g. C8, C18). The mobile phase contained at least 25% aqueous phase.
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 939-183-5
- EC Number:
- 939-183-5
- IUPAC Name:
- 939-183-5
- Details on test material:
- Identification: ERC#18
Description: clear colorless liquid
Batch: 9114460/002
Purity: 100% (UVCB)
Expiry / Retest Date: 23 January 2013
Storage Conditions: room temperature in the dark
Constituent 1
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- > 6.5
- pH:
- 6.74
Any other information on results incl. tables
Results
Preliminary estimate
The log10Powwas calculated to be: 5.50 to
6.48
The full KOWWIN calculation is presented in Appendix 2(Attachment 3 of
this summary).
Definitive Test
Please see Attachment 4 for Typical Chromatography.
Calibration
The retention times of the deadtime and the retention times, capacity factors (k') and log10Powvalues for the reference standards are shown in the following tables:
Table 1
Dead Time |
Retention Time (mins) |
Mean Retention Time (mins) |
|
Injection 1 |
Injection 2 |
||
Thiourea |
2.507 |
2.512 |
2.510 |
Table 2
Standard |
Retention Time (mins) |
Mean Retention Time (mins) |
Capacity Factor (k') |
Log10k' |
Log10Pow |
|
|
Injection 1 |
Injection 2 |
|
|
|
|
Benzene |
4.475 |
4.480 |
4.478 |
0.784 |
-0.106 |
2.1 |
Toluene |
5.583 |
5.588 |
5.586 |
1.23 |
8.83 x 10-2 |
2.7 |
Naphthalene |
6.351 |
6.361 |
6.356 |
1.53 |
0.185 |
3.6 |
Phenanthrene |
9.665 |
9.684 |
9.674 |
2.86 |
0.456 |
4.5 |
Triphenylamine |
21.312 |
21.336 |
21.324 |
7.50 |
0.875 |
5.7 |
DDT |
30.943 |
30.948 |
30.945 |
11.3 |
1.05 |
6.5 |
Partition coefficient of sample
The retention times, capacity factor and log10Powvalue determined for the sample are shown in the following table:
Table 3
Peak |
Injection |
Retention Time (mins) |
Capacity Factor (k') |
Log10k' |
Log10Pow |
1 |
1 |
42.460 |
> 11.3 |
> 1.05 |
> 6.5 |
2 |
42.431 |
> 11.3 |
> 1.05 |
> 6.5 |
|
2 |
1 |
43.487 |
> 11.3 |
> 1.05 |
> 6.5 |
2 |
43.522 |
> 11.3 |
> 1.05 |
> 6.5 |
|
3 |
1 |
43.881 |
> 11.3 |
> 1.05 |
> 6.5 |
2 |
43.894 |
> 11.3 |
> 1.05 |
> 6.5 |
|
4 |
1 |
44.273 |
> 11.3 |
> 1.05 |
> 6.5 |
2 |
44.303 |
> 11.3 |
> 1.05 |
> 6.5 |
Overall log10Pow: > 6.5
Partition coefficient: > 3.16 x 106
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient of the test item has been determined to be greater than 3.16 x 10E6, log10 Pow > 6.5.
- Executive summary:
The determination was carried out using the HPLC Method designed to be compatible with Method A8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
The test system consisted of a high performance liquid chromatograph with a suitable detector (UV/). A reverse phase HPLC column with a very low percentage of polar groups was used (e.g. C8, C18). The mobile phase contained at least 25% aqueous phase.
The partition coefficient of the test item has been determined to be greater than 3.16 x 106, log10 Pow> 6.5.
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