Registration Dossier
Registration Dossier
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EC number: 268-358-2 | CAS number: 68081-84-5 This substance is identified by SDA Substance Name: C10-C16 alkyl glycidyl ether and SDA Reporting Number: 15-076-00.
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- From 1988-08-04 to 1988-08-11
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Cited from ECHA disseminated dossier Query date: 2015-07-22 For justification of read across please refer to IUCLID section 13.
Data source
Reference
- Reference Type:
- other: ECHA disseminated dossier
- Title:
- No information
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Alcohols, C13-15-branched and linear
- EC Number:
- 287-625-4
- EC Name:
- Alcohols, C13-15-branched and linear
- Cas Number:
- 85566-16-1
- IUPAC Name:
- 85566-16-1
- Details on test material:
- - Name of test material: Alkyl (C13-C15) glycidylether
- Physical state: Liquid
- Lot/batch No.: DC 1295.3
- Stability under test conditions: Stable
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 2 males and 1 female
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Average score: 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- other: Average score. 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- other: Average score: 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Average score: 0
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 13
- Remarks on result:
- other: Average score: 0
Any other information on results incl. tables
Eye irritation scores:
Time |
Animal |
Sex |
Cornea opacity |
Iris |
Conjunctivae |
Cumul.Score |
Mean Cumul. Score |
|
Redn. |
Chem. |
|||||||
1HR |
27 |
M |
0 |
0 |
1 |
0 |
1 |
1.33 |
28 |
M |
0 |
0 |
1 |
1 |
2 |
||
29 |
F |
0 |
0 |
1 |
0 |
1 |
||
24HRS |
27 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
28 |
M |
0 |
0 |
0 |
0 |
0 |
||
29 |
F |
0 |
0 |
0 |
0 |
0 |
||
48HRS |
27 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
28 |
M |
0 |
0 |
0 |
0 |
0 |
||
29 |
F |
0 |
0 |
0 |
0 |
0 |
||
72HRS |
27 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
28 |
M |
0 |
0 |
0 |
0 |
0 |
||
29 |
F |
0 |
0 |
0 |
0 |
0 |
||
Results:
Toxic symptoms / Mortality
No acute toxic symptoms were observed in the animals during the test period, and no mortality occurred.
Irritation
Alkyl (C13-C15) glycidylether showed a primary irritation score of 0.33, when applied undiluted to the rabbit eye mucosa.
Coloration
No corrosion of the cornea was observed at any of the measuring intervals.
Body weights
The body weight gain of all rabbits was similar.
Necropsy
No necropsy was performed. All animals were killed and discarded.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
