Registration Dossier
Registration Dossier
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EC number: 229-912-9 | CAS number: 6834-92-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, but no information on purity of test substance.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Reference Type:
- secondary source
- Title:
- Soluble Silicates. CAS No. 1344-09-8, 6834-92-0, 10213-79-3, 13517-24-3 and 1312-76-1.
- Author:
- OECD SIDS
- Year:
- 2 004
- Bibliographic source:
- SIDS Initial Assessment Report for SIAM 18 Paris, France 20-23 April, 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- Inveresk Research International
Test material
- Reference substance name:
- Disodium metasilicate
- EC Number:
- 229-912-9
- EC Name:
- Disodium metasilicate
- Cas Number:
- 6834-92-0
- Molecular formula:
- H2O3Si.2Na Soluble Silicates Category
- IUPAC Name:
- disodium oxosilanediolate
- Details on test material:
- SOURCE: EKA Kemi AB
PURITY: Not reported
IMPURITY/ADDITIVE/ETC.: Not reported
ANY OTHER INFORMATION: Sodium metasilicate (anhydrous).
Applied as moistened substance (concentration not indicated).
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Sex: Male
- Source: Cheshire Rabbit Farms ltd.
- Age: approx. 11 weeks
- Weight at study initiation: 2.3 - 3.0 kg
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- 5 days
- Number of animals:
- 1
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Time point:
- other: 1, 24, 48, 72 hours and 5 days
- Score:
- 8
- Reversibility:
- not reversible
- Remarks:
- Effects persisted for up to 5 days after exposure
- Remarks on result:
- other: Some evidence of necrosis was observed. When the test substance was applied as dry powder, no erythema and oedema was observed.
Any other information on results incl. tables
AVERAGE SCORE:
- Erythema: 4
- Edema: 4
No further details on "results" available.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
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