Registration Dossier

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics, other
Type of information:
experimental study
Adequacy of study:
other information

Data source

Reference
Reference Type:
review article or handbook
Title:
Urea. CAS No. 57-13-6
Author:
OECD SIDS (Organisation for Economic Co-operation and Development Screening Information Data Set)
Year:
2002
Bibliographic source:
https://hpvchemicals.oecd.org/UI/handler.axd?id=89564308-0887-4614-8a20-e542ce76221a

Materials and methods

Objective of study:
other: excretion in urine and sweat; blood concentration of endogenous urea
Principles of method if other than guideline:
- Parameters analysed / observed: excretion urea in urine and sweat; concentration urea in blood
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Urea
EC Number:
200-315-5
EC Name:
Urea
Cas Number:
57-13-6
Molecular formula:
CH4N2O
IUPAC Name:
urea
Details on test material:
It is assumed that the purity is 100%

Test animals

Species:
other: human adult

Administration / exposure

Route of administration:
other: endogeneous urea
Details on study design:
Physiological concentrations in man were determined.

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on distribution in tissues:
The blood concentration of urea is also relatively high, 3.3-6.7 mmol/L (200-500 mg/L)
Details on excretion:
Urea is an endogenous product of protein and amino acid catabolism, and consequently 20-35g (200-500 mg/kg body weight/day) of urea is excreted daily in human urine, in sweat 120-570 mg/L.

Applicant's summary and conclusion

Conclusions:
Urea is an endogenous product of protein and amino acid catabolism. Concentrations of endogenous urea in adult human are as follows:
In urine 20-35 g/24h (200-500 mg/kg body weight/day)
In sweat 120-570 mg/L
In blood 3.3-6.7 mmol/L (200-500 mg/L).
Executive summary:

Urea is an endogenous product of protein and amino acid catabolism. Concentrations of endogenous urea in adult human are as follows:

In urine 20-35 g/24h (200-500 mg/kg body weight/day)

In sweat 120-570 mg/L

In blood 3.3-6.7 mmol/L (200-500 mg/L).