Registration Dossier
Registration Dossier
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EC number: 290-058-5 | CAS number: 90063-97-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Mentha arvensis, Labiatae.
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Calculation of toxicity using constituent data generated by EcoWin v1.00 QSAR. methodology according to EFEO NCS protocol.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: NCS protocol
- Deviations:
- no
- Principles of method if other than guideline:
- NCSs being complex mixtures that are often very poorly water soluble and highly volatile, create special difficulties with the present test protocols which will require adaptation. Instead, the ecotoxicity was estimated using a QSAR and by read across from the constituents.
The combined toxicity of each NCS is calculated based on the ecotoxicity of the constituents according to the additivity formula in line with the NCS protocol (see attached file "formula.doc").
Calculated data for the constituents are obtained from the QSAR EcoWin v1.00. - GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not relevant - Details on sampling:
- Not relevant
- Details on test solutions:
- Not relevant
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- No data
- Post exposure observation period:
- Not relevant
- Hardness:
- No data
- Test temperature:
- No data
- pH:
- No data
- Dissolved oxygen:
- No data
- Salinity:
- Not relevant
- Nominal and measured concentrations:
- Not relevant
- Details on test conditions:
- Not relevant
- Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2.43 mg/L
- Details on results:
- No data
- Results with reference substance (positive control):
- No data
- Reported statistics and error estimates:
- No data
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The acute toxicity (48h-EC50) of Cornmint oil towards Daphnia magna is 2.43 mg/l.
- Executive summary:
The acute toxicity of Cornmintoil towards Daphnia magna was estimated using the QSAR EcoWin v1.00 according to the NCS protocol. 48h-EC50 values were calculated for individual constituents using QSARs for one or more relevant chemical groups to which the respective constituent belongs. The worst case EC50 values (from different QSARs) for each for the constituents were used to calculate the EC50 of Cornmint oil according to the formula given in the NCS protocol (see attached file "formula.doc").
The 48h-EC50 of Cornmint oil towards Daphnia magna was calculated to be 2.43 mg/l.
Reference
Estimated ecotoxicity values of Cornmint oil constituents towards Daphnia magna in mg/l.
(When more than one Ecosar class wass considered justified, the class resulting in the lowest toxicity value was used).
| Substance | CAS | Ecosar class | Daphnia 48hEC50 (est) in mg/l |
| L-menthol | 2216-51-5 | Neutral organics | 5.074 |
| Menthone | 89-80-5 | Neutral organics | 13.087 |
| L-limonene | 5989-54-8 | Neutral organics | 0.292 |
| beta-Pinene | 127-91-3 | Neutral organics | 0.721 |
| 1,8-cineole | 470-82-6 | Neutral organics | 7.98 |
| alpha-Pinene | 7785-70-8 | Neutral organics | 0.835 |
| Iso-menthone | 491-07-6 | Neutral organics | 13.087 |
| Neo-menthol | 2216-52-6 | Neutral organics | 5.074 |
| Methyl acetate | 16409-45-3 | esters / Neutral organic SAR (baseline toxicity) | 1.125 |
| Piperitone | 89-81-6 | Vinyl/allyl ketones / Neutral organic SAR (baseline toxicity) | 9.521 |
| Pulegone | 89-82-7 | Vinyl/allyl ketones / Neutral organic SAR (baseline toxicity) | 7.512 |
| Iso-Pulegol | 89-79-2 | Neutral organics | 7.588 |
| Germacrene-D | 37839-63-7 | Neutral organics | Substance outside applicability domain of QSAR; no toxicity at saturation expected |
| Neo-iso-pulegol | 89-79-2 | Neutral organics | 7.588 |
| Octan-3-ol | 589-98-0 | Neutral organics | 14.316 |
| Neo-iso-menthol | 89-78-1 | Neutral organics | 5.074 |
| Beta-caryophyllene | 87-44-5 | Neutral organics | Substance outside applicability domain of QSAR; no toxicity at saturation expected |
| Sabinene | 3387-41-5 | Neutral organics | 0.379 |
| Myrcene | 123-35-3 | Neutral organics | 0.266 |
The log Kow values for Germacene-D and beta-Caryophyllene lie outside the applicability domain of the QSAR. Therefore, as no toxicity is predicted by the QSAR at saturation, these substances are left out of the calculation of the toxicity of the mixture.
Description of key information
48h-EC50: 2.43 mg/l
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.43 mg/L
Additional information
The acute toxicity of Cornmintoil towards Daphnia magna was estimated using the QSAR EcoWin v1.00 according to the NCS protocol. 48h-EC50 values were calculated for individual constituents using QSARs for one or more relevant chemical groups to which the respective constituent belongs. The worst case EC50 values (from different QSARs) for each for the constituents were used to calculate the EC50 of Cornmint oil according to the formula given in the NCS protocol .
The 48h-EC50 of Cornmint oil towards Daphnia magna was calculated to be 2.43 mg/l.
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