Registration Dossier
Registration Dossier
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EC number: 290-058-5 | CAS number: 90063-97-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Mentha arvensis, Labiatae.
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Test according to unspecified guideline. Very concise reporting: chemical identity of test substance, origin, strain, sex, housing conditions, and health status of animals, testing conditions, and non lethal effects not reported. However, report is acceptable as basic data.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no data on guideline available
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Standard acute method, no details available.
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- cornmint oil
- IUPAC Name:
- cornmint oil
- Details on test material:
- - Name of test material (as cited in study report): Cornmint oil
- Lot/batch No.: confidential
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- no data
- Doses:
- 0.5, 1.2, 1.6 and 5 g/kg body weight
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
- Preliminary study:
- no applicable
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1.24 other: g/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: within 24 hours
- Mortality:
- 0.5 g/kg - 1/10
1.2 g/kg - 5/10
1.6 g/kg - 6/10
5 g/kg - 10/10 - Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
Distribution of Mortality
| Observation Day | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 |
| Mortality | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Acute Tox. 4
- Remarks:
- Based on CLP criteria
- Conclusions:
- The acute oral toxicity (LD50) of Cornmint oil towards rats is 1.24 g/kg bw under the conditions of this test. Based on this result the substance should be classified as Acute Tox. 4 in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
- Executive summary:
The acute toxicity (LD50) of Cornmint oil towards rats was investigated according to a standard acute method (unspecified guideline). Rats were exposed to a single oral dose of 0.5, 1.2, 1.6 and 5 g/kg bw and were observed for 14 days. Per dose 10 rats were used. The acute toxicity (LD50) was found to be 1.24 g/kg bw under the conditions of this test.
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