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Administrative data

Link to relevant study record(s)

Description of key information

No specific toxicokinetics studies have been performed on this substance, and none are proposed.
Toxicokinetic studies would be complicated by the corrosive effects. Indeed, in a standard 28 day oral study in rats, clinical and haemotological parameter changes were consistent with gross tissue damage arising from feeding the animals with a known corrosive. This masks the detection of more subtle parameter changes derived from inherent substance toxicity.
In the Chemical Safety Report and eSDS, prevention of exposure to the substance is provided by the strict Risk Management Measures in place. Operators exposed to the substance would experience immediate irritation
It is possible to surmise the likely metabolism of this substance, a tertiary amine.
Dermal absorption of tertiary amines is possible because they have low molecular weights (< 200 Daltons). These compounds are expected to be well absorbed in the respiratory and gastro-intestinal tracts.
The water solubility of the substance favors extensive and even systemic distribution via the circulatory system.
There is a commonality in the metabolism of the tertiary amines. N-oxide formation and excretion of both freebase and N-oxide forms, with some dealkylation, appears to be the major route of excretion for the lower molecular weight tertiary amines.
QSAR indicates extensive metabolism; the production of a number of highly water-soluble metabolites favors urinary excretion and indicates that bioaccumulation is unlikely.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information