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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

The key study for the acute fish toxicity of the substance was based upon the results of an acute toxicity study which tested the effects of a supporting substance (N;N;N';N'';N''-Pentamethyldipropylentriamin) on zebra fish (Brachydanio rerio HAM. and BUCH.), based upon read-across from a supporting substance (structural analogue or surrogate).  This test was conducted in accordance with OECD 203 (April 1984, updated July 1992).  

Key value for chemical safety assessment

LC50 for freshwater fish:
100 mg/L

Additional information

An acute toxicity study on the effects of a N;N;N';N'';N''-Pentamethyldipropylentriamin on zebra fish (Brachdanio rerio HAM. and BUCH.) was the key study for the short-term toxicity to fish endpoint, based upon read-across from a supporting substance (structural analogue or surrogate). Based on nominal concentrations, the 96-h LC50 was reported as ca. 100 mg/L. Mortality occurred first at the concentration of 46.4 mg/L (nominal). Other substance-related effects were the symptoms of apathy, tumbling, and swimming near the water surface. The NOEC was reported as 21.5 mg/L (nominal). Based on the arithmetic mean values of the analytically detected concentrations after 1+96 hours, the LC50 was reported at about 92.5 mg/L. The pH adjustment of a parallel group with the highest nominal concentration (464 mg/L) did not significantly reduce mortality and toxic signs.

A supporting study on the acute fish toxicity of the substance was conducted as part of a fish bioaccumulation study, which evaluated the effects of the substance on himedaka (Oryzias latipes); this study resulted in a 48-h TLm (median lethal dose) of 430 mg/L. The 96-h test on zebra fish is considered to be more reliable test; the LC50 value is lower than the TLm value reported from the 48-h test on himedaka and is used as the key value for the LC50.