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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non GLP, non guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report Date:
1987

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No data.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
gas under pressure: refrigerated liquefied gas

Test animals

Species:
rabbit

Test system

Type of coverage:
open
Preparation of test site:
other: abraded and unabraded
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
0.5ml
Duration of treatment / exposure:
4-72 hours
Observation period:
30 days
Number of animals:
18
6 per group

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: Corrosion score
Basis:
mean
Time point:
other: 4 hours
Score:
3
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: Corrosive effects on intact and abraded skin, not reversible after 30 days.
Irritation parameter:
other: Corrosion score
Basis:
mean
Time point:
other: 24 hours
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: Corrosive effects on intact and abraded skin, not reversible after 30 days.
Irritation parameter:
other: Corrosion score
Basis:
mean
Time point:
other: 48 hours
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: Corrosive effects on intact and abraded skin, not reversible after 30 days.
Irritation parameter:
other: Corrosion score
Basis:
mean
Time point:
other: 72 hours
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: Corrosive effects on intact and abraded skin, not reversible after 30 days.
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 4 Hours
Score:
4
Max. score:
4
Reversibility:
not reversible
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 hours
Score:
4
Max. score:
4
Reversibility:
not reversible
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 48 hours
Score:
4
Max. score:
4
Reversibility:
not reversible
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 72 hours
Score:
4
Max. score:
4
Reversibility:
not reversible
Irritant / corrosive response data:
The substance is severely corrosive to the skin of rabbits. Corrosive effects observed on intact and abraded skin, not reversible after 30 days.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance is severely corrosive to the skin of rabbits. Corrosive effects observed on intact and abraded skin, not reversible after 30 days.