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Diss Factsheets
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EC number: 205-411-0 | CAS number: 140-31-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2e: Meets generally accepted scientific standards, well-documented and acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- No information
- Author:
- Smyth, H.F. et al
- Year:
- 1 962
- Bibliographic source:
- Am Ind Hyg Assoc J, vol 23 ; p. 95
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 956
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Rats were exposed to a concentrated vapor for 8 hours and observed for 14 days.
- GLP compliance:
- not specified
- Test type:
- other:
- Limit test:
- yes
Test material
- Reference substance name:
- 2-piperazin-1-ylethylamine
- EC Number:
- 205-411-0
- EC Name:
- 2-piperazin-1-ylethylamine
- Cas Number:
- 140-31-8
- Molecular formula:
- C6H15N3
- IUPAC Name:
- 2-piperazin-1-ylethanamine
- Details on test material:
- AEP reported to contain 2.5% diethylenetriamine.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Although rat strain was not specifically identified, it is believed to be Carworth-Wistar strain since that is used for acute oral toxicity study conducted in the same laboratory.
Administration / exposure
- Route of administration:
- other: inhalation: saturated vapour
- Type of inhalation exposure:
- other: not stated in report but expected to be whole body given the study date
- Vehicle:
- other: no data
- Details on inhalation exposure:
- Concentrated vapor inhalation consists of subjecting groups of six female albino rats to a flowing stream of vapor-ladened air. The vapor-air mixture is generated by passing 2.5 L/min of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch in in approximately 50 ml of test chemical contained in a gas-washing bottle
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- Not applicable
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- A group of 6 female rats were exposed to saturated vapor for 8 hours and observed for 14 days.
- Statistics:
- No additional information available.
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- male/female
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: Concentrated vapor generated at room temperature is not a hazard in single exposures.
- Mortality:
- No mortality observed at 8 hour exposure time at saturated vapour pressure at 20ºC.
- Clinical signs:
- other: No additional information available.
- Body weight:
- No additional information available.
- Gross pathology:
- No additional information available
- Other findings:
- No additional information available.
Any other information on results incl. tables
Not possible to determine LC50 from this information.
Applicant's summary and conclusion
- Conclusions:
- Not possible to determine LC50 from this information.
- Executive summary:
The acute toxicity of vapors of aminoethylpiperazine (AEP) was examined. Based on this study, there was no lethality observed in rats exposed to the vapors of AEP for 8 hours.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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