Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Not applicable
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: 2e: Meets generally accepted scientific standards, well-documented and acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
No information
Author:
Smyth, H.F. et al
Year:
1962
Bibliographic source:
Am Ind Hyg Assoc J, vol 23 ; p. 95
Reference Type:
publication
Title:
Unnamed
Year:
1956

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Rats were exposed to a concentrated vapor for 8 hours and observed for 14 days.
GLP compliance:
not specified
Test type:
other:
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-piperazin-1-ylethylamine
EC Number:
205-411-0
EC Name:
2-piperazin-1-ylethylamine
Cas Number:
140-31-8
Molecular formula:
C6H15N3
IUPAC Name:
2-piperazin-1-ylethanamine
Details on test material:
AEP reported to contain 2.5% diethylenetriamine.

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
female
Details on test animals or test system and environmental conditions:
Although rat strain was not specifically identified, it is believed to be Carworth-Wistar strain since that is used for acute oral toxicity study conducted in the same laboratory.

Administration / exposure

Route of administration:
other: inhalation: saturated vapour
Type of inhalation exposure:
other: not stated in report but expected to be whole body given the study date
Vehicle:
other: no data
Details on inhalation exposure:
Concentrated vapor inhalation consists of subjecting groups of six female albino rats to a flowing stream of vapor-ladened air. The vapor-air mixture is generated by passing 2.5 L/min of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch in in approximately 50 ml of test chemical contained in a gas-washing bottle
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
Not applicable
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
A group of 6 female rats were exposed to saturated vapor for 8 hours and observed for 14 days.
Statistics:
No additional information available.

Results and discussion

Preliminary study:
Not applicable
Effect levels
Sex:
male/female
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: Concentrated vapor generated at room temperature is not a hazard in single exposures.
Mortality:
No mortality observed at 8 hour exposure time at saturated vapour pressure at 20ºC.
Clinical signs:
other: No additional information available.
Body weight:
No additional information available.
Gross pathology:
No additional information available
Other findings:
No additional information available.

Any other information on results incl. tables

Not possible to determine LC50 from this information.

Applicant's summary and conclusion

Conclusions:
Not possible to determine LC50 from this information.
Executive summary:

The acute toxicity of vapors of aminoethylpiperazine (AEP) was examined. Based on this study, there was no lethality observed in rats exposed to the vapors of AEP for 8 hours.