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EC number: 500-234-8
CAS number: 68891-38-3
1 - 2.5 moles ethoxylated
Oral LD50 (OECD 401), rat = 2870 mg/kg bwDermal LD50 (OECD 402), rat > 2000 mg/kg bw (limit test)Acute toxicity by inhalation was not tested according to REGULATION (EC) No 1907/2006, Annex VIII, Section 8.5, Column 2
1: Absolute Body Weights in g and Body Weight Gain in %
Animal No. / Sex
21 / male
22 / male
23 / male
24 / male
25 / male
Mean ± SD
229 ± 5.3 g
242 ± 5.6 g
280 ± 8.5 g
22 ± 3.0 %
26 / female
27 / female
28 / female
29 / female
30 / female
217 ± 6.8 g
217 ± 8.6 g
227 ± 14.6 g
4 ± 3.9 %
The acute toxicity of AES (C12-14, 1-2.5 EO) Na (CAS 68891-38-3) has
been extensively evaluated in numerous oral and dermal toxicity studies.
Additionally read across from structurally related AES, i.e.
AES (C12-14, 1-2.5 EO) TIPA (CAS 174450-50-1), AES (C10-16) Na (CAS
68585-34-2) and AES (C8-10, 1-2.5 EO) Na was performed. The AES reported
within the AES category show similar structural, physico-chemical,
environmental and toxicological properties. The approach of grouping
different AES for the evaluation of their effects on human health and
the environment was also made by the Danish EPA (2001) and HERA (2003),
supporting the read across approach between structurally related AES.
For details please refer to the category justification attached in
IUCLID section 13.
The oral LD50 values based on the test material were all at least above
2 g/kg and the same result was achieved for the dermal route when tested.
Acute toxicity by inhalation was not tested as according to REGULATION
(EC) No 1907/2006, Annex VIII, Section 8.5, Column 2.
In summary, no classification is warranted for either route of acute
The following information is taken into account for any hazard / risk
Many high quality studies investigating the acute toxicity of alcohol
ethoxysulfates (AESs) have shown that in terms of acute toxicity the use
of these compounds are of low concern. They are of low oral and dermal
Danish EPA - Environmental and Health Assessment of Substances in
Household Detergents and Cosmetic Detergent Products (2001).
Environmental Project No. 615, pp. 24-28
HERA (2003). Human & Environmental Risk Assessment on ingredients of
European household cleaning products Alcohol Ethoxysulphates, Human
Health Risk Assessment Draft, 2003. http: //www. heraproject. com.
The available data on acute toxicity do not meet the criteria for
classification according to Regulation (EC) No. 1272/2008, and are
therefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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