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Key value for chemical safety assessment

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There are no toxicokinetic studies available with N-Vinylformamide (VFA). Therefore, the following toxicokinetic assessment is based on the available information on physico-chemical parameters and results from other toxicity studies with VFA:


VFA is a liquid with a vapour pressure of 0.21 hPa at 20°C, has a molecular weight of 71.08 g/mol and a log Pow of -0.11 at 24°C.


Acute oral toxicity studies in rats provide evidence for systemic availability of VFA by the oral route (based on the observed clinical symptoms and the LD50 of > 1000 < 2000 mg/kg). In an acute dermal toxicity study in rabbits no signs of systemic toxicity of VFA were observed. Therefore, dermal absorption of VFA is expected to be rather low.

Results from the available repeated dose inhalation toxicity study in rats indicate systemic availability of VFA by this exposure route. In this study, the liver was the main target organ of systemic toxicity, but the kidney also represented a target organ at the highest concentration indicative for distribution of VFA to these organs.

The results from several in vitro genotoxicity studies with and without metabolic activation indicate that no reactive metabolite was formed after the addition of rat liver S9 mix.

Based on the log Pow of -0.11 VFA is expected to be not bioaccumulative. VFA is not stable in water and is expected to slowly hydrolyse at neutral pH to acetaldehyde and formamide.