Registration Dossier
Registration Dossier
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EC number: 219-137-4 | CAS number: 2370-88-9
Dissociation constant
Administrative data
Link to relevant study record(s)
Description of key information
Study is scientifically unjustified
Key value for chemical safety assessment
Additional information
In accordance with column 2 of REACH Annex VII, the Dissociation constant study does not need to be conducted as the substance is hydrolytically unstable (half-life less than 12 hours at pH 4, 7 and 9).
There are no reliable measured data for the dissociation constant of methylsilanetriol. The typical dissociation constants for the hydroxyl protons of silanetriols are available from studies in other silanetriols. It is appropriate to read-across dissociation constant data for methylsilanetriol from phenylsilanetriol. This suggests that silanols are not expected to undergo significant dissociation within the range of pH relevant in the environment orin vivo.
Phenylsilanetriol has a measured first dissociation constant approximately 10 in a reliable study using a relevant test method. Additional information is given in a supporting report (PFA 2013b) attached in Section 13.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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