Dodecyl acrylate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1964

Report date:

1964

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

no

Principles of method if other than guideline:

Method: BASF-Test

GLP compliance:

no

Test type:

other: Inhalation hazard test

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-Propenoic acid, C12-14-alkyl esters

EC Number:

282-516-8

EC Name:

2-Propenoic acid, C12-14-alkyl esters

Cas Number:

84238-60-8

Molecular formula:

Unspecified

IUPAC Name:

2-Propenoic acid, C12-14-alkyl esters

Test material form:

other:

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

air

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

0.69 mg/L

No. of animals per sex per dose:

6

Control animals:

not specified

Details on study design:

This test (also called inhalation risk test) was performed in principle as described in OECD Guideline 403. It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at the temperature chosen for vapor generation (here 20 °C). Groups of 3 rats per sex were exposed to the vapors, generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 hours. For confirmation of the results, the experiment was repeated once. No analytical determination of the atmosphere concentrations was performed.
The nominal concentration was calculated as quotient of the amount of test substance weight loss during the exposure and the amount of air used during the exposure.

Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight of groups was determined before the start of
the study and at the end of the observation period in the surviving animals. The clinical signs and findings were reported in summarized form. Upon completion of the study, all animals were sacrificed and submitted to gross-pathological examination. The study allows for an estimate of the length of time required to cause severe toxic effects resulting from exposure to an atmosphere saturated with volatile components of the test substance.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 0.69 mg/L air

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: no mortality occured

Mortality:

No mortality occurred within 8 hours and during the post-exposure period of 7 days after inhalation of a highly saturated vapor-air mixture of the test compound.

Clinical signs:

other: No clinical signs or symptoms were noted.

Gross pathology:

No macroscopic pathologic abnormalities were noted in the surviving animals examined at the end of the observation period.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met