Dodecyl acrylate

Short-term toxicity to fish

Description of key information

2-Propenoic acid, C12-14-alkyl ester was tested in a 96 h-aquatic study to fish. The LC50 was ca. 460 mg/L and the NOEC was 215 mg/L.

In the short term toxicity test to fish the LC50 value of the test substance, 2-Propenoic acid, C16-18-alkyl esters (read across) based on the loading rate was determined to be >100 mg/L. Based on this result the LC50 value of 2-Propenoic acid, octadecyl ester is also considered to be >100 mg/L.  

In an acute toxicity test to Zebrafish of the test substance, 2 -Propenoic acid, C18 -26 -alkyl esters, the NOEL was laid down as 100 mg/L. The LL50 after 96 hours was > 100 mg/L. All effect levels are given based on the nominal level of the test item. Therefore the test substance was found to cause no toxic effects to Zebrafish after 96 hours when tested with a loading level of 100 mg/L.

In a study with 2 -Propylheptyl acrylate, no toxic effects occured within the range of water solubility of the tested substance in this 96-h static fish test (LC50: >0.31 mg/L).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

460 mg/L

Additional information

2 -Propenoic acid, C12 -14 -alkyl ester was tested in a 96 h- acute toxicity study to golden orfe according to DIN 38412. The nomial concentrations were 0, 100, 215, 464 and 1000 mg/L. The observed symptoms were apathy, narcotic-like state, tumbling. The LC100 and the LC50 were 1000 mg/L and 215 mg/L. The NOEC-value and the LC0 were 215 mg/L and 215 mg/L.         

In the supporting study, the test item was tested in a 96 h toxicity study to Pimephales promelas. The nominal test concentrations were 0, 1.6, 2.47, 3.8, 5.85, 9.00 mg/L. Observations of fish behaviour, mortality and signs of intoxication were recorded at 0, 24, 48, 72 and 96 hours. The highest exposure (4.34 mg/L) was near saturation for this chemical. The fish were stressed throughout the duration of the test, but no mortalities occurred. No behavioral observations were recorded.  

The acute lethal toxicity of 2-Propenoic acid, C16-18-alkyl esters to Danio rerio (Zebrafish) (read across) was investigated under static exposure conditions over a period of 96 h. The singly applied loading rate was 100 mg/L.GC-FID analysis of the test substance was conducted in the definitive test at the beginning of the test and after 24, 48, 72 and 96 h of incubation. The test concentration was below the quantification limit of 0.02 mg/L throughout the test. Thus, evaluation was based on the loading rate. At the loading rate of 100 mg/L, none of a total of seven fish died after 96 h of exposure. No mortality was observed in the blank control. Toxic effects other than mortality, e.g. loss of coordination, hypo- or hyperactivity and swimming on the back, were not observed.The no-observed-effect concentration (NOEC) was 100 mg/L with respect to the loading rate. 100% mortality (LC100) could not be detected. Based on the binominal theory, the absence of mortality provides at least 99% confidence that the LC50 is greater than the applied loading rate of 100 mg/L.

The toxicity of 2-propylheptyl acrylate to Danio rerio was tested in a GLP study according to OECD guideline 203. 7 zebra fish were exposed to the test item in a static test for 96 hours at nominal concentrations of 0 and 100 mg/L. No mortality or toxic signs were observed. The LC50 (96 h) was estimated to be > 0.31 mg/L (measured) since the saturation concentration could not be reliably determined. The determined water solubility is 0.2 mg/L, therefore 2-propylheptyl acrylate shows no toxic effects in the range of water solubility. [BASF SE 2009]

Based on this result the LC50 value of 2-Propenoic acid, dodecyl ester is also considered to be above the water solubility.