Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-857-3 | CAS number: 127-68-4
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- other: only orientating information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium 3-nitrobenzenesulphonate
- EC Number:
- 204-857-3
- EC Name:
- Sodium 3-nitrobenzenesulphonate
- Cas Number:
- 127-68-4
- Molecular formula:
- C6H5NO5S.Na
- IUPAC Name:
- sodium 3-nitrobenzenesulphonate
- Details on test material:
- Name of the test substance used in the study report: Ludigol
purity: 95%
Constituent 1
Test animals
- Species:
- cat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- water
- Duration of treatment / exposure:
- 2 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2x1000 mg/kg , 1x2000 mg/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- Two cats (one male, one female) were injected intravenously with a 25% or a 40% aqueous solution of the test substance on consecutive days. The animals received a dose of 1000 mg/kg b.w. twice, followed by a single dose of 2000 mg/kg b.w..
Results and discussion
Results of examinations
- Details on results:
- After injection of 1000 mg/kg, the animals had temporary atony; increased salivation, accelerated breathing and disturbance of equilibrium was observed in one cat. The second injection of 2000 mg/kg b.w. led to apnea for about 35 seconds, followed by atony and assumption of a lateral position. The animals recovered within 10-15 minutes. The injection sites were oedematic and lividly discolored. The hemogram revealed no pathological findings.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
