Registration Dossier
Registration Dossier
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EC number: 204-857-3 | CAS number: 127-68-4
Endpoint summary
Administrative data
Description of key information
Additional information
Between 35% and 45% of American women dye their hair, often at monthly intervals, over a period of years (CTFA, 1993). This estimate is drawn from market research data on hair dye product use, generally from females aged 15-60. A number of epidemiologic studies have investigated the association between cancer and occupation as a hairdresser or barber and between cancer and personal use of hair dyes. The World Health Organization's International Agency for Research on Cancer (lARC) empaneled a Working Group on the Evaluation of Carcinogenic Risks to Humans to review all available data on these issues. The Working Group met October 6-13, 1992, in Lyon. France (IARC, 1993). The change to the IARC Working Group was to ascertain that all appropriate data had been collected and were being reviewed, to evaluate the results of the epidemiological and experimental studies and prepare accurate summaries of the data, and to make an overall evaluation of the carcinogenicity of exposure to humans. The IARC Working Group concluded that "there is inadequate evidence that personal use of hair colourants entails exposures that are carcinogenic." Hence: "Personal use of hair colourants cannot be evaluated as to its carcinogenicity (Group 3)". The IARC Working Group also concluded that: "there is limited evidence that occupation as a hairdresser or barber entails exposures that are carcinogenic." Hence: "Occupation as a hairdresser or barber entails exposures that are probably carcinogenic (Group 2A)" (lARC. 1993). The Expert Panel concludes that the relevance of the occupational data and conclusion to individuals using hair dyes is unclear.
Source: J. of American College of Toxicology 15(4), 1996
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