Registration Dossier
Registration Dossier
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EC number: 263-423-1 | CAS number: 62125-22-8
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (56 d) ≥ 1000 mg/kg dw for Eisenia fetida (OECD 222)
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity to soil macroorganisms of2,2-bis[[(1-oxoisooctadecyl)oxy]methyl]-1,3-propanediyl bis(isooctadecanoate) (CAS 62125-22-8)are available for this endpoint, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read across to four structurally related group members fatty acids, C16-18 and C18-unsatd., tetraesters with pentaerythritol (CAS 68604-44-4), 2,2-bis(hydroxymethyl)-1,3-propanediyl dioleate (CAS 25151-96-6), fatty acids, C16-18 and C18-unsaturated, esters with pentaerythritol (CAS 85711-45-1) and decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) was conducted. The target as well as the first three read-across substances both exhibit longer fatty acid chain lengths (≥ C16) and pentaerythritol. The other read-across substance covers the other end of the group with shorter fatty acid chains (C5-C10). This read-across is justified in detail in the overall summary (IUCLID chapter 6.3) and within the category justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. Nevertheless, as it can be seen in the data matrix of the category justification in section 13 and the overall summary, all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results.
Chronic tests with the group members 2,2-bis(hydroxymethyl)-1,3-propanediyl dioleate (CAS 25151-96-6), fatty acids, C16-18 and C18-unsaturated, esters with pentaerythritol (CAS 85711-45-1) and fatty acids, C16-18 and C18-unsatd., tetraesters with pentaerythritol (CAS 68604-44-4) were conducted according to OECD 222 under GLP conditions. No mortality or effects on reproduction of earthworms up to 1000 mg/kg dw soil occurred in any of these three tests. An acute test according to OECD 207 with the third read-across substance decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) did not result in any mortalities in the treatment group exposed to 1000 mg/kg dw soil.
Based on the results from structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by an equal ecotoxicological profile, it can be concluded that2,2-bis[[(1-oxoisooctadecyl)oxy]methyl]-1,3-propanediyl bis(isooctadecanoate) (CAS 62125-22-8)will not exhibit effects on soil macroorganisms.
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