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EC number: 263-423-1 | CAS number: 62125-22-8
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EL50 (16 h) > 10000 mg/L (ISO 10712)
Key value for chemical safety assessment
Additional information
Two studies investigating the toxicity of2,2-bis[[(1-oxoisooctadecyl)oxy]methyl]-1,3-propanediyl bis(isooctadecanoate) (CAS 62125-22-8)are available. The most recent and reliable study was conducted under static conditions according to ISO 10712 and to ‘German Water Hazard Classification Scheme’ investigating aquatic microorganisms (Mead, 1997). In this GLP study an aqueous suspension of Pseudomonas putida was used as inoculum. A nominal test concentration of 10000 mg/L was used (prepared as WAF). The test substance did not inhibit the growth of Pseudomonas putida. Hence, the 16 h-EL50 was determined to be > 10000 mg/L based on the nominal test concentration.
This outcome is confirmed by the result of the toxicity control of the biodegradation study with the test substance (Desmares-Koopmans, 1997). This study investigating the biodegradation of the test substancewas tested in a CO2 evolution Test according to OECD guideline 301B using domestic sludge as inoculum. The test also consisted of a toxicity control.The toxicity control was tested at a test concentration of 15.6 mg/L. The toxicity control attained 31.3% degradation after 8 days of incubation (52.7% after 15 days). In accordance with the OECD Guideline 301 if in a toxicity test, containing both the test substance and a reference compound, more than 25% degradation (based on total ThOD or ThCO2) occurred within 14 days, the test substance can be assumed to be non inhibitory to microbial organisms. It can therefore be concluded that2,2-bis[[(1-oxoisooctadecyl)oxy]methyl]-1,3-propanediyl bis(isooctadecanoate) (CAS 62125-22-8)will not exhibit effects to aquatic microorganism up to the limit of water solubility. The test item concentration in the toxicity control of 15.6 mg/L can be used as NOEC value for the toxicity to aquatic microorganisms.As it can be seen in the data matrix of the category justification in section 13 and the overall endpoint summary IUCLID 6.1, all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results, i.e. no microbial inhibition and no toxic effects were observed to aquatic organisms up to the limit of water solubility.
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