Pentacarbonyliron

Neurotoxicity

Administrative data

Endpoint:

neurotoxicity: acute inhalation

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: basic information given, scientifically acceptable

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: EPA OPP 81-3 (acute inhalation toxicity)

GLP compliance:

yes

Remarks:

testing lab.

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Pentacarbonyliron

EC Number:

236-670-8

EC Name:

Pentacarbonyliron

Cas Number:

13463-40-6

Molecular formula:

C5FeO5

IUPAC Name:

pentacarbonyliron

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Duration of treatment / exposure:

4 h

Doses / concentrations

Remarks:

Doses / Concentrations:
5.2, 17, 28, 60 ppm
Basis:

No. of animals per sex per dose:

5

Control animals:

yes

Examinations

Neurobehavioural examinations performed and frequency:

Neurological examination was performed prior to exposure and at 1 and 4 hours post-exposure.

Results and discussion

Results of examinations

Details on results:

A treatment-related pattern was seen during the first 2 days after exposure at the 3 high levels. The most common finding was flaccidity of body tone on the day after exposure. The 60 ppm animals also showed flaccidity of limb tone, decreased to pinch, righting and startle reflex, and ataxia. The control and 5.2 ppm animals were comparable.

Effect levels

Basis for effect level:

other: see 'Remark'

Remarks on result:

not measured/tested

Remarks:

Effect level not specified