Flue dust, portland cement

Skin sensitisation

Administrative data

Endpoint:

skin sensitisation

Remarks:

other: epidemiological assessment

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study results of this epidemiological study apply for cement, a product which is about a factor of 20 to 100 more prevalent than Flue dust.

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Year:

2003

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

epidemiological assessment

GLP compliance:

not specified

Type of study:

other: epidemiological review

Test material

Test material information

Constituent 1

Reference substance name:

Cement, portland, chemicals

EC Number:

266-043-4

EC Name:

Cement, portland, chemicals

Cas Number:

65997-15-1

Constituent 2

Reference substance name:

cement clinker production and application

IUPAC Name:

cement clinker production and application

Results and discussion

In vivo (non-LLNA)

Results

Reading:

other: epidemiological assessment

Dose level:

not applicable

Remarks on result:

other: Reading: other: epidemiological assessment. Dose level: not applicable.

Any other information on results incl. tables

The endpoint study record describes the results of an epidemiological study and not the results of a test.

Applicant's summary and conclusion

Conclusions:

The available epidemiological literature provides documentation that supports the hypothesis of a relationship between Cr(VI) in wet cement and allergic dermatitis in construction workers.

Executive summary:

Chromium, especially hexavalent chromium, is a well known skin sensitiser, and it is assumed th sensitisation reactions in cement workers are the result of the content of hexavalent chromium in cement. Some countries have since the 1980s had legislation which regulates the concentration of the chromium in the cement. A decline in the occurence of cement induced chromium allergy which have been reported during the last 20 -30 years have been attributed to this measure. However, the epidemiological evidence for such a relationship has been questioned. therefore this review of the available epidemiological literature on chromium allergy related to wet cement was carried out. The following two questions were adressed specifically:

- Does Cr(VI) in wet cement cause allergic dermatitis in construction workers?

- Is there any causal association between the reduction of Cr(VI) in cement and the occurence of allergic dermatitis?

The available epidemiological literature supports the hypothesis of a relationship between the chromium (i.e. Cr(VI)) in wet cement and allergic dermatitis in construction workers. there was not found epidemioligical evidence to conclude that there is a causal association between the reduction of Cr(VI) in cement and the reduced occurence of allergic dermatitis. However, although the documentation is relatively sparse, the available documentation indicates such a relationship.