Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
publication
Title:
Toxic effects of copper phthalocyanine-based dyes.
Author:
Kurlandsky BA, Torshina NL and Balabanova EL
Year:
1993
Bibliographic source:
Current Toxicology 1 (3/4): 243-246

Materials and methods

Principles of method if other than guideline:
No data given.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32 copper
EC Number:
205-685-1
EC Name:
29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32 copper
Cas Number:
147-14-8
Molecular formula:
C32H16CuN8
IUPAC Name:
[29H,31H-phthalocyaninato(2-)-kappa~2~N~29~,N~31~]copper
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
- Name of test material (as cited in study report): Pigment Blue 15
- Analytical purity: no data given

Test animals

Species:
rat
Strain:
other: albino rats
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: DMSO
Doses:
3000 mg/kg bw
No. of animals per sex per dose:
No data given.
Control animals:
not specified
Details on study design:
No data given.

Results and discussion

Mortality:
No information was given regarding mortality of the animals.
Clinical signs:
The authors of the publication reported the following clinical signs:
- A reduction of diuresis (test -2.1 +- 0.19 ml, control -7.3 +- 0.6 ml) and an increasing of the protein content in urea (test 2.3 +- 0.19 mg/ml, control 1.86 +- 0.07 mg/ml) was seen.
- No test substance or the products of its metabolism were found in the blood.
- The increasing of Cu2+ content in the blood serum of the test animals (in test 1.80+-0.08 mg/ml, in control 1.60+-0.02 mg/ml) was connected with the content of up to 0.2% of the soluble copper salts in the pigment, and was reversible after removing the Cu2+ impurity.

Applicant's summary and conclusion