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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
No information
Author:
Neuzil E, Bailenger J
Year:
1952
Bibliographic source:
C.r. Seanc. Soc. Biol. 146: 1108
Reference Type:
secondary source
Title:
Toxicity Profile Phthalocyanine blue
Author:
BIBRA Information Services Ltd.
Year:
2005

Materials and methods

Principles of method if other than guideline:
No data given.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32 copper
EC Number:
205-685-1
EC Name:
29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32 copper
Cas Number:
147-14-8
Molecular formula:
C32H16CuN8
IUPAC Name:
[29H,31H-phthalocyaninato(2-)-kappa~2~N~29~,N~31~]copper
Test material form:
solid: particulate/powder

Test animals

Species:
other: rabbit and guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intravenous
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
No data given.
Frequency of treatment:
No data given.
Doses / concentrationsopen allclose all
Dose / conc.:
40 mg/kg bw/day
Remarks:
Doses / Concentrations:
Doses of approx. 40 mg/kg bw/day in rabbits for at least one month.
Dose / conc.:
100 mg/kg bw/day
Remarks:
Doses / Concentrations:
Doses of [probably] 100 mg/kg bw/day in guinea pigs.
No. of animals per sex per dose:
No data given.
Control animals:
not specified
Details on study design:
No data given.

Examinations

Observations and examinations performed and frequency:
No data given.
Sacrifice and pathology:
No data given.
Other examinations:
No data given.

Results and discussion

Results of examinations

Details on results:
No weight loss or effects on red blood cells were seen in rabbits. Doses applied in guinea pigs were similarly not overtly toxic.

Target system / organ toxicity

Critical effects observed:
no

Applicant's summary and conclusion