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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

Acumulation of CAS 147 -14 -8 in aquatic organisms does not expected.

Key value for chemical safety assessment

Additional information

No experimental data for the assessment of bioaccumulation potential of CAS 574 -93 -6 are available.

However, based on its structure and its physico-chemical properties a transportation of the substance through biological membranes can be excluded. Therefore, its bioaccumulative potential can be stated as very low and further testing is not proposed according to Annex IX, column 2, point 9.3.3.

This assumption is supported by a read-across.This read-across approach consists of the experimental data from two structural similar substances CAS 1328-53-6 and CAS 147-14-8. Both studies were performed according to OECD 305C with Cyprinus carpio as test species. Test organisms were exposed to different concentrations of the substances for 6 weeks in a flow-through system.For the source substance CAS 147-14-8 the BCF was determined to be less or equal than 3.6 for a concentration of 0.06 mg/l. Whereas a concentration of 0.6 mg/l resulted in a BCF being in the range between 0.33 and 11 L/kg (NITE, J-CHECK, 1979). Comparable results were obtained for the source CAS 1328-53-6. The test organisms were exposed to 0.1 mg/l and 0.01 mg/l of the test item. The BCFs were determined being in the range between 0.51 and 74 L/kg (NITE, J-CHECK, 1992). The solubility of the test substance and its source substances in octanol and in water is extremely low. However,based on solubility ratio, the Log Kow was calculated for the source substances CAS 1328-53-6 and CAS 147-14-8 being in the range between -1.6 and -0.4.Therefore, bioaccumulation of the substances is not expected.

Based on the substances's structure and its physico-chemical properties and the supproting read-across approach using experimental data from the structurally similar substances CAS 1328-53-6 and CAS 147-14-8 it can be concluded that acumulation of CAS 574 -93 -6 in aquatic organisms does not expected.

Based on its structure and its physico-chemical properties a transportation of the substance through biological membranes can be excluded. Therefore, its bioaccumulative potential can be stated as very low and further testing is not proposed according to Annex IX, column 2, point 9.3.3.

This assumption is supported by the experimental data from the substance. The study was performed according to OECD 305C with Cyprinus carpio as test species. Test organisms were exposed to different concentrations of the substances for 6 weeks in a flow-through system.The test organisms were exposed to 0.1 mg/l and 0.01 mg/l of the test item. The BCF was determined to be less or equal than 3.6 for a concentration of 0.06 mg/l. Whereas a concentration of 0.6 mg/l resulted in a BCF being in the range between 0.33 and 11 L/kg (NITE, J-CHECK, 1979). However,based on solubility ratio, the Log Kow was calculated for the CAS 147 -14 -8 being in the range between -1.6 and -1.0.Therefore, bioaccumulation of the substances is not expected.

Based on the substances'sstructure and its physico-chemical propertiesand the availebleexperimental data, it can be concluded that acumulation of CAS 1328 -53 -6 in aquatic organisms does not expected.