Registration Dossier
Registration Dossier
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EC number: 200-662-2 | CAS number: 67-64-1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Daphnia pulex (fresh water species): 48h LC50=8800 mg/L (nominal)
Artemia salina (marine invertebrate): 24 h LC50=2100 mg/L (nominal)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- LC50
- Effect concentration:
- 8 800 mg/L
Marine water invertebrates
Marine water invertebrates
- Dose descriptor:
- LC50
- Effect concentration:
- 2 100 mg/L
Additional information
No tests performed according to current standard guidelines for short-term toxicity to invertebrates (e.g. OECD 202) are available. Several reliable studies, however, were carried out according to national standard methods and comparable to current guidelines. All available tests were performed under static test conditions. Analytical monitoring of test substance concentrations were not performed. Based on the results of the acute fish toxicity testing, the moderate volatility of acetone from aqueous solution seems to be of little importance. In a study carried out in analogy to the concept rules of the Dutch Standardization Institute a 48 hour LC50=8800 mg/L (nominal) was determined for Daphnia pulex and a 48 hour LC50 in the range between 12600 and 12700 mg/L (nominal) for Daphnia magna. In a further study conducted comparable to OECD guideline 202 and using Daphnia magna as test organism the 48 hour LC50 was determined to be 30806 mg/L (nominal). Two studies dealing with the toxicity of acetone towards marine invertebrates are available. For the brine shrimp Artemia salina, a 24 hour LC50=2100 mg/L (nominal) was determined. In a further study the acute toxicity of acetone towards the harpaticoid Nitocra spinipes (brackish water crustacean) was investigated according to a method developed at The Brackish Water Toxicology Laboratory in Studsvik, Sweden (Swedish Environment Protection Board). The 96 hour LC50 was determined to be 16700 mg/L (nominal). Additional non-guideline toxicity tests performed with crustaceans, insects, and molluscs support the conclusion that acetone is of low acute toxicity to invertebrates (LC50 values >=7000 mg/L). For example, the 48 h LC50 and NOEC of the fresh water snail Lymnaea stagnalis were determined to be 7000 mg/L and 3500 mg/L (nominal), respectively.
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