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Ecotoxicological information

Toxicity to microorganisms

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Key value for chemical safety assessment

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No toxicity studies have been carried out on micro-organisms with HFOs. Composition information, derived using two dimensional gas chromatography, has been used in conjunction with the PETROTOX model to calculate this endpoint.

The aquatic toxicity was estimated using the PETROTOX computer model, which combines a partitioning model (used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading) with the Target Lipid Model (used to calculate acute and chronic toxicity of non-polar narcotic chemicals). PETROTOX computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a petroleum substance and membrane-water partition coefficients (Kmw) that describe the partitioning of the hydrocarbons between the water and organism. The estimated 72-hr LL50 value for Tetrahymena pyriformis, one of the most sensitive microorganism species, is >1000 mg/L and the estimated NOEL is 14.91 mg/L (Redman et al., 2010b).