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EC number: 295-511-0 | CAS number: 92061-97-7 A complex combination of hydrocarbons produced as the residual fraction from the distillation of the products from a catalytic cracking process. It consists predominantly of hydrocarbons having carbon numbers predominantly greater than C11 and boiling above approximately 200°C (392°F).
Selected results for the acetone treated groups (reflecting the lower NOAEL obtained for these animals); presented as mean [SD]: Red blood cell count (million/mm3): Male: 7.806 [0.343], 7.574 [0.540], 7.628 [0.356], 7.746 [0.595], 6.866 [0.518]**, 6.870 [0.522]** Female: 7.294 [0.627], 7.230 [0.664], 7.052 [0.263], 6.552 [0.611], 6.228 [1.165] Haematocrit (%): Males: 43.02 [2.35], 41.52 [2.83], 42.14 [2.55], 41.58 [2.21], 37.46 [2.80]**, 37.36 [2.61]** Females: 41.04 [3.59], 40.22 [3.97], 40.48 [2.48], 36.64 [8.32], 37.40 [3.25], 34.56 [6.58]* Haemoglobin concentration (g/dL): Males: 15.38 [0.57], 15.15 [0.38], 15.23 [0.54], 15.34 [0.57], 14.06 [1.10]**, 13.60 [0.89]** Females: 14.97 [0.51], 15.20 [0.78], 14.68 [0.57], 14.74 [0.74], 14.08 [0.62], 12.51 [1.30]** Blood urea nitrogen (mg/dL): Males: 16.1 [2.1], 15.1 [1.4], 14.6 [1.3], 15.3 [2.0], 18.8 [3.5], 20.1 [3.5]** Females: 14.8 [2.3],15.8 [2.1], 16.3 [2.9], 16.7 [2.7], 17.4 [1.4], 19.9 [4.8]* Serum cholesterol (mg/dL): Males: 37.7 [8.1], 45.3 [13.0], 38.2 [10.4], 35.7 [6.0], 43.0 [10.8], 42.0 [11.0] Females: 43.6 [9.9], 46.1 [9.0], 48.4 [11.5], 49.5 [14.0], 64.1 [12.8]*, 85.5 [32.4]** SGPT (IU/L): Males: 43.9 [7.2], 40.3 [7.8], 36.3 [5.0]*, 38.4 [3.7], 33.2 [7.3]**, 31.5 [3.5]** Females: 34.7 [4.7], 33.1 [5.2], 32.7 [4.8], 30.7 [5.1], 29.2 [5.4], 28.1 [6.5] Relative liver weight (g/g bw): Males: 0.0294 [0.0017], 0.0293 [0.0008], 0.0299 [0.0015], 0.0295 [0.0019], 0.0318 [0.0013]*, 0.0378 [0.0023]** Females: 0.0323 [0.0021], 0.0319 [0.0022], 0.0338 [0.0020], 0.0343 [0.0023], 0.0367 [0.0031]*, 0.0437 [0.0051]** Dose levels: 0, 0.01, 0.1, 1, 10 or 50 mg/kg bw/d * = P<0.05; ** = P<0.01
The sub-acute dermal toxicity of FCCU clarified oil (F-115-01) was investigated in male and female SD after application neat (0, 1, 10 or 50 mg/Kg bw/d) or diluted in acetone (0, 0.01, 0.1, 1.0, 10 or 50 mg/Kg bw/d). All animals survived until scheduled study end, with clinical signs restricted to not clearly dose-related slight irritation of the test site (including barely perceptible or slight erythema, drying/flaking, slight eschar) in the low and intermediate dose groups (both treated neat and diluted with acetone) but absent from the majority of high dose animals. The overall irritancy of a given dose of F-115-01 appeared to be slightly greater after dilution with acetone than when applied neat.
In animals treated with neat test substance, body weight was significantly decreased in high dose females from study day 22 and in high dose males at study end. Haematological analyses revealed significant decrements in RBC, HCT and HGB from high dose males with platelet count significantly decreased in high dose females. Blood urea nitrogen was elevated significantly in high dose animals of both sexes, while serum cholesterol was significantly increased in high dose females and potassium significantly increased in females at 10 mg/Kg bw/d and above. Organ weight measurements at necropsy revealed that absolute thymus weights were significantly decreased in high dose males and females, with relative thymus weight decreased also (significant in females only). In addition, relative liver weights were significantly increased in high dose males and in females given 10 mg/Kg bw/d and above, however no histopathological assessment was performed on tissues from these animals treated with neat test sample.
No effect of treatment on body weight was apparent in any group receiving F-115-01 in acetone, however significant decreases in RBC, HCT and HGB were present in males receiving 10 mg/Kg bw/d and above, with HCT and HGB decreased (significant) in high dose females also. Platelet counts were significantly decreased in high dose females. Clinical chemistry analysis revealed that BUN was elevated significantly in high dose males and females, with serum cholesterol levels approximately doubled in high dose females only (males unaffected). SGPT activity was decreased significantly in females receiving 0.1-50 mg/Kg bw/d, however the toxicological relevance of this observation is unclear. Findings at necropsy in high dose animals of both sexes treated with F-115-01 in acetone included a significant increase in absolute liver weight and a significant decrease in absolute thymus weight. Comparable alterations were apparent also in relative liver weight and relative thymus weight for these groups of animals, with relative liver weight increased in both sexes receiving 10 mg/kg bw/d. Histopathological evaluation of tissues from control and high dose (acetone-vehicle) animals revealed trace to mild acanthosis and hyperkeratosis in skin from the test site (more evident in females than in males) but no apparently treatment-related changes in any other tissue (including those exhibiting weight changes, as discussed above).
The NOAEL for systemic toxicity for the neat sample in males was 10 mg/Kg bw/day (based on decreased body weight, altered haematological and clinical parameters and organ weight effects) and 1 mg/Kg bw/d in females (reflecting changes in serum potassium and an increased relative liver weight). The LOAEL for local effects was 1 mg/Kg bw/d for both sexes (based on sporadic, very slight skin irritation).
The NOAEL for systemic toxicity for the sample applied in acetone was 1 mg/Kg bw/day in both sexes (based on decreased haematological parameters and/or increased relative liver weight) with a LOAEL for local effects of 0.01 mg/Kg bw/d for both sexes (based on sporadic, very slight skin irritation).
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