Registration Dossier

Ecotoxicological information

Long-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

No chronic toxicity studies have been carried out on fish with HFOs. Composition information, derived using two dimensional gas chromatography, has been used in conjunction with the PETROTOX model to calculate this endpoint.

The aquatic toxicity was estimated using the PETROTOX computer model, which combines a partitioning model (used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading) with the Target Lipid Model (used to calculate acute and chronic toxicity of non-polar narcotic chemicals). PETROTOX computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a petroleum substance and membrane-water partition coefficients (Kmw) that describe the partitioning of the hydrocarbons between the water and organism. The estimated freshwater fish NOEL (No Observed Effect Level) value is 0.1 mg/L based on mortality (Redman et al., 2010b).