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Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27 May 2010 to 09 July 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
This study has been performed according to OECD and EC guidelines and according to GLP principles. The test substance is adequately characterised. Therefore full validation applies.
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
thermal analysis
Remarks:
ThermoGravimetric Analysis (TGA) + Differential Scanning Calorimetry (DSC)
Melting / freezing pt.:
-45 - -35
Atm. press.:
1 024 hPa
Remarks on result:
other: freezing (liquid-solid transition)
Key result
Melting / freezing pt.:
-26 °C
Atm. press.:
1 024 hPa
Remarks on result:
other: melting (solid-liquid transition)

Results - Main Study

During cooling an exothermic peak was observed between -35°C and -45°C. The effect was obtained due to crystallization of the test substance.

During heating an exothermic peak between -40°C and -60°C was observed. This peak was due to further crystallization of the test substance. After crystallization an endothermic peak was observed between -40°C and 0°C, which was caused by melting. The extrapolated onset temperature of the peak was -25.98°C.

 

With the second experiment similar results as with the first experiment were obtained. The extrapolated onset temperature of the melting peak was determined to be -25.29°C.

Executive summary:

Both freezing and melting temperatures of Aluminium chloride hydroxide sulphate (as aqueous solution) were determined according to OECD/EC guidelines, DSC method. Two assays were performed under nitrogen. Freezing was observed when cooling between -35 and -45°C, the reverse melting transition was recorded at ca -26°C.

Description of key information

Freezing range between -35 and -45°C, melting at ca -26°C (on aqueous solution as manufactured).

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
-26 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study. Both transitions were recorded, freezing was observed in a 10°C-range of temperature, melting occured as a sharp transition, so the single value was retained as key data for purpose of CSA.

As an UVCB, it should be noted that the value of the parameter may show some variations.

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