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EC number: 254-400-7 | CAS number: 39290-78-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 29 June 1972 - 26 September 1972
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Study was conducted before the introduction of GLP and not according to an OECD guideline. Only one concentration tested (nominal).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 413 (Subchronic Inhalation Toxicity: 90-Day Study)
- Deviations:
- yes
- Remarks:
- Pre-guideline study
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- no
- Remarks:
- pre-GLP study
- Limit test:
- yes
Test material
- Test material form:
- other: aerosol
- Remarks:
- solid/liquid
- Details on test material:
- - Name of test material (as cited in study report): Aluminiumhydroxychlorid
- Substance type: Aerosol
- Physical state: Solid/Liquid
- Composition of test material, percentage of components: Confidential information
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Remarks:
- (exposure room of 10 m3)
- Vehicle:
- other: unchanged (no vehicle)
- Remarks on MMAD:
- MMAD / GSD: No data
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 65 seconds (1x10 and 11x5 seconds) in 6 hours on exposure days
- Frequency of treatment:
- 65 times in 90 days
Doses / concentrations
- Dose / conc.:
- 15.3 mg/m³ air (nominal)
- Remarks:
- Doses / Concentrations:
Deodorant spray, 9.0% Aluminiumhydroxichlorid
Basis:
nominal conc.
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent no treatment
Results and discussion
Results of examinations
- Mortality:
- mortality observed, non-treatment-related
- Description (incidence):
- One male rat died after 62 days of inhalation without clear symptoms
- Body weight and weight changes:
- no effects observed
- Description (incidence and severity):
- No adverse effects were observed on body weight
- Haematological findings:
- no effects observed
- Description (incidence and severity):
- No adverse effects were observed on blood as well as albumine/globuline in blood and enzyme activities
- Urinalysis findings:
- no effects observed
- Description (incidence and severity):
- No adverse effects were observed urine
- Description (incidence and severity):
- Organ weights were normal.
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Macro and microscopic examination: All animals in the test group showed moderate phagocytose in the lungs and small dust spread into lymph peribronchial lymph nodes.
Effect levels
- Dose descriptor:
- LOAEC
- Effect level:
- 15.3 mg/m³ air (nominal)
- Based on:
- other: Deodorant spray, 9.0% Aluminiumhydroxichlorid
- Sex:
- male/female
- Basis for effect level:
- other: Moderate phagocytose in the lungs and small dust spread into lymph peribronchial lymph nodes
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The daily amount of deodorant sprayed averaged 121.6 g. In the course of 90 days, in total 7785 g of product was sprayed .The entire Locron P consumption is therefore about 700 g. The concentration of deodorant in the exposure room was approximately 170 mg/m3 in the first 10 seconds of the first exposure. It is unclear what the average exposure concentration of test substance was.
Applicant's summary and conclusion
- Conclusions:
- LOAEC = 15.3 mg/m3. Some pathological effects were found: All animals in the test group showed moderate phagocytose in the lungs and small dust spread into lymph peribronchial lymph nodes at the tested concentration and under the conditions of this study.
- Executive summary:
The effects of 90-day exposure of rats to deodorant spray containing 9% aluminiumhydroxychloride was tested in this inhalation study. 10 male and 10 female rats were exposed, while another 10 males and females formed the control group.
Clinical signs, body weights, blood and urine and macro and microscopic abnormalities were recorded.
One male rat died after 62 days of inhalation without clear symptoms. No adverse effects were observed on body weight, blood and urine, as well as albumine/globuline in blood and enzymeactivities. Organ weights were also normal.
Macro and microscopic examination showed moderate phagocytose in the lungs and small dust spread into lymph peribronchial lymph nodes in all animals.
A LOAEC of 15.3 mg/m3 could be established (only concentration tested).
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